Circulating, soluble adhesion proteins in cerebrospinal fluid and serum of patients with multiple sclerosis: correlation with clinical activity

Annals of Neurology
P Dore-DuffyM Peterson

Abstract

Soluble adhesion protein intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule (E-selectin) were measured in serum and cerebrospinal fluid (CSF) of patients with relapsing-remitting multiple sclerosis (RRMS) in remission and in exacerbation, as well as patients with chronic progressive MS, stable MS, and in patients with other neurological and inflammatory diseases (ONDs). Serum ICAM-1 and E-selectin were significantly elevated in patients with MS over those with ONDs and controls. CSF VCAM-1 and E-selectin were found to be elevated over control and disease control samples. No increase in CSF ICAM-1 was observed. Results were analyzed longitudinally and by MS category. In paired CSF and serum samples from patients in exacerbation, elevated VCAM-1 correlated with increased serum VCAM-1 in 5 of 7 patients. Elevated CSF E-selectin did not correlate with elevations in serum E-selectin.

References

Apr 1, 1992·The Journal of Experimental Medicine·L C DunlopM C Berndt
Feb 1, 1992·Journal of Neuroscience Research·K RösslerH Lassmann
Mar 1, 1992·Immunology Today·Y ShimizuS Shaw
Oct 1, 1990·Transplantation·J S Pober, R S Cotran
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M P BevilacquaM A Gimbrone
Aug 1, 1986·The Journal of Experimental Medicine·R S CotranJ S Pober
Oct 1, 1993·Immunology Today·A J Gearing, W Newman

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Citations

Mar 1, 2002·Muscle & Nerve·Tomoko ItoTomiyasu Tsuda
Oct 26, 1995·Journal of Immunological Methods·J SperlP W Askenase
Jun 17, 2005·Journal of Neuroimmunology·Fabrizio GiulianiV Wee Yong
Feb 28, 2002·Journal of the Neurological Sciences·Jarmila WagnerovaPaula Dore-Duffy
Jun 27, 2002·Journal of the Neurological Sciences·G V McDonnell, S A Hawkins
Jul 17, 2003·Journal of Neuroimmunology·Jorge Correale, María de los Milagros Bassani Molinas
Aug 4, 1998·Journal of Neuroimmunology·A A PetersenG L Vejlsgaard
May 5, 1999·Journal of Neuroimmunology·A WindhagenF Heidenreich
Jun 16, 2001·International Immunopharmacology·L M OssegeJ P Malin
Apr 30, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Munire KilincRana Karabudak
Jan 1, 1997·Acta Neurologica Scandinavica·T KumamotoT Tsuda
May 1, 1997·Acta Neurologica Scandinavica·D FranciottaV Cosi
Jan 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·G GiovannoniE J Thompson
May 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·G V McDonnell, S A Hawkins
Dec 1, 1996·Pediatric Research·E S Buescher, I Malinowska
Nov 6, 2013·Immunotherapy·Stefano Angiari, Gabriela Constantin
Dec 12, 1997·Journal of the Neurological Sciences·G MartinoL M Grimaldi
Sep 23, 2014·BMC Neuroscience·Beatriz Marcos-RamiroEva Cernuda-Morollón
Mar 2, 1999·Microvascular Research·P Dore-DuffyJ C LaManna
Aug 3, 1999·Journal of Neuroimmunology·S J Lee, E N Benveniste
Jun 18, 1998·Journal of Neuroimmunology·G V McDonnellS A Hawkins
Apr 29, 2011·Progress in Neurobiology·Ulf ZiemannHayrettin Tumani
Jan 13, 2010·Journal of the Neurological Sciences·Thomas LiggettVictor Levenson
Dec 3, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M UkkonenI Elovaara
Feb 24, 2010·Acta Neurologica Scandinavica·Krystyna Mitosek-SzewczykE Belniak
Feb 8, 2005·Journal of the Neurological Sciences·M RentzosD Vassilopoulos
Sep 27, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·J D BleeckerJ D Reuck
May 12, 2009·Neurobiology of Disease·Hayrettin TumaniUNKNOWN BioMS Study Group
Jul 14, 2010·Biochimica Et Biophysica Acta·Jorge Ivan AlvarezAlexandre Prat

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