Circulating Soluble Fas and Fas Ligand Levels Are Elevated in Children with Nonalcoholic Steatohepatitis

Digestive Diseases and Sciences
Naim AlkhouriValerio Nobili

Abstract

There is an urgent need to develop alternatives to liver biopsy in children to diagnose nonalcoholic steatohepatitis (NASH), the aggressive form of nonalcoholic fatty liver disease (NAFLD). Increased hepatocyte apoptosis plays a central role in the development of NASH. To evaluate the plasma levels of two markers of apoptosis, soluble Fas (sFas) and soluble Fas ligand (sFasL), in children with NAFLD and assess their utility as biomarkers of disease severity. Children with biopsy-proven NAFLD were included, and blood samples were collected. Patients were divided into NASH and "not NASH." We measured plasma sFas and sFasL using specific ELISA immunoassays. One hundred and seventeen children with NAFLD were recruited. Average age was 12.2 ± 2.9 years, 67 % were male, and 58 % had NASH. Patients with NASH had significantly higher levels of sFas and sFasL than patients in the "not NASH" group (686.0 ± 186.5 pg/mL versus 594.2 ± 244.9, p = 0.023 for sFas and 324.9 ± 146.5 pg/mL versus 221.4 ± 134.0, p < 0.001 for sFasL). sFasL was found to have higher accuracy for predicting the presence of NASH on liver biopsy with an AUC (95 % CI) of 0.714 (0.618, 0.810). A prediction model, the NASH apoptosis score, was generated consisting of pla...Continue Reading

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Citations

Mar 15, 2016·Metabolism: Clinical and Experimental·Naim Alkhouri, Ariel E Feldstein
Mar 11, 2016·Metabolism: Clinical and Experimental·Maricruz CrespoNaim Alkhouri
Dec 5, 2017·Lipids in Health and Disease·Shui-Xian DuWen-Wen Jin
Jul 28, 2020·Expert Review of Gastroenterology & Hepatology·Antonella MoscaAnna Alisi
Oct 1, 2016·World Journal of Gastroenterology : WJG·Maria Grazia ClementePietro Vajro
Jul 12, 2018·World Journal of Gastroenterology : WJG·Tatsuo KandaMitsuhiko Moriyama
Oct 20, 2020·Frontiers in Cell and Developmental Biology·Mariana Joaquim, Mafalda Escobar-Henriques
Jul 3, 2021·Pediatric Reports·Angeliki PapachristodoulouAntonia Sioga

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis