Circulating soluble receptor for advanced glycation end products is decreased and inversely associated with acute phase response in chronic spontaneous urticaria

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
A Kasperska-ZajacA Grzanka

Abstract

Activation of receptor for advanced glycation end products (RAGE) leads to the proinflammatory response and the release of its soluble form (sRAGE) which appears to function as an anti-inflammatory feedback mechanism. To determine serum sRAGE concentration in CSU patients and its association with C-reactive protein (CRP) concentration, a nonspecific inflammatory marker of the disease activity. Concentrations of sRAGE and CRP were measured in serum of CSU patients and compared with the healthy controls. Serum sRAGE concentrations were significantly decreased in CSU patients, especially those more severely affected. In addition, significant inverse correlations were observed between sRAGE and CRP concentrations. Down-regulation of sRAGE and its association with acute phase response suggest a role for RAGE activation in the pathogenesis of CSU. It seems that lower serum sRAGE concentration may enhance the urticarial processes.

References

May 8, 1999·The British Journal of Dermatology·R A SabroeM W Greaves
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Colomba FalconeDiego Geroldi
Jul 1, 2005·Arthritis Research & Therapy·Bernhard MoserAnn Marie Schmidt
May 30, 2009·Journal of Leukocyte Biology·Ravichandran RamasamyAnn Marie Schmidt
Jun 22, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·R AseroA Tedeschi
Feb 4, 2014·Journal of Inflammation·Alicja GrzankaAlicja Kasperska-Zajac
Sep 3, 2014·BioMed Research International·Alicja GrzankaAlicja Kasperska-Zajac
May 20, 2015·Cytokine·A Kasperska-ZajacE Machura
Dec 25, 2015·PloS One·Alicja Kasperska-ZajacAleksandra Damasiewicz-Bodzek

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Citations

Oct 18, 2016·Clinical and Experimental Dermatology·A Kasperska-ZającJ Zamłyński
Dec 23, 2017·International Journal of Immunopathology and Pharmacology·Alicja Kasperska-ZającAlicja Grzanka

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