Circulating sST2 and catestatin levels in patients with acute worsening of heart failure: a report from the CATSTAT-HF study.

ESC Heart Failure
Josip A BorovacJosko Bozic

Abstract

Soluble suppression of tumourigenicity 2 (sST2) and catestatin (CST) reflect myocardial fibrosis and sympathetic overactivity during the acute worsening of heart failure (AWHF). We aimed to determine serum levels and associations of sST2 and CST with in-hospital death as well as the association between sST2 and CST among AWHF patients. A total of 96 AWHF patients were consecutively enrolled, while levels of sST2 and CST were determined and compared between non-survivors and survivors. Predictive values of sST2 and CST for in-hospital death were determined by the penalized multivariable Firth logistic regression. The diagnostic ability of sST2 and CST for in-hospital death was assessed by the receiver operating characteristic analysis and examined with respect to the N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin I, and C-reactive protein. The in-hospital death rate was 6.25%. Serum sST2 and CST levels were significantly higher among non-survivors than survivors [146.6 (inter-quartile range, IQR 65.9-156.2) vs. 35.3 (IQR 20.6-64.4) ng/mL, P < 0.001, and 19.8 (IQR 9.9-28.0) vs. 5.6 (IQR 3.4-9.8) ng/mL, P < 0.001, respectively]. Both sST2 and CST were independent predictors of in-hospital d...Continue Reading

References

Sep 8, 2001·The American Journal of Cardiology·C OpasichUNKNOWN Italian Network on Congestive Heart Failure (IN-CHF) Investigators
Nov 28, 2009·Journal of the American College of Cardiology·Domingo A Pascual-FigalUNKNOWN MUSIC Investigators
May 4, 2010·American Heart Journal·Christopher M O'ConnorUNKNOWN Efficacy of Vasopressin Antagonism in heart Failure Outcome Study with Tolvaptan (EVEREST) investigators
Dec 14, 2011·Critical Care : the Official Journal of the Critical Care Forum·Jindrich SpinarJiri Jarkovsky
Nov 30, 2013·Cardiology Clinics·Liviu Klein, Henry Hsia
May 14, 2014·Journal of Cardiovascular Translational Research·Nagendu B DevSucheta M Vaingankar
May 23, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe RistagnoUNKNOWN FINNRESUSCI Study Group
Jan 30, 2016·Journal of Cardiovascular Pharmacology and Therapeutics·Dandan WangCongxin Huang
Oct 30, 2016·European Journal of Heart Failure·Mattia ArrigoUNKNOWN GREAT Network
Apr 27, 2017·Current Medicinal Chemistry·Sushil K MahataNitish R Mahapatra
Nov 4, 2017·Journal of the American College of Cardiology·Laura C van VarkUNKNOWN TRIUMPH Investigators
Nov 21, 2017·Heart Failure Clinics·Cian P McCarthy, James L Januzzi
Nov 6, 2018·Journal of the American College of Cardiology·Michele EmdinJames L Januzzi
Aug 2, 2019·Journal of Clinical Medicine·Josip A BorovacJosko Bozic

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Citations

Dec 16, 2020·International Journal of Molecular Sciences·Stathis DimitropoulosDimitris Tousoulis
Jun 26, 2021·World Journal of Diabetes·Marko KumricJosko Bozic
Sep 4, 2021·Scandinavian Journal of Rheumatology·F GüntherB Ehrenstein

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Methods Mentioned

BETA
X‐ray

Clinical Trials Mentioned

NCT03389386

Software Mentioned

CRT

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