Circulating TNF-α levels increased and correlated negatively with IGF-I in postoperative cognitive dysfunction

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Jue JiangHong Jiang

Abstract

Signaling pathways of tumor necrosis factor-α (TNF-α) and insulin-like growth factor-I (IGF-I) are found to be functionally interrelated in some experimental studies. IGF-I may be involved in the pathogenesis of postoperative cognitive dysfunction (POCD). In order to investigate the possible interaction of TNF-α and IGF-I in POCD, the plasma levels of IGF-I and TNF-α were determined in 44 patients under general anesthesia. As compared with non-POCD patients, POCD patients showed increased TNF-α and decreased IGF-I levels in plasma, as well as a significant negative correlation between TNF-α and IGF-I values. The present results suggest that interaction of increased TNF-α levels and decreased IGF-1 levels might lead to a vicious circle, which may contribute to POCD.

References

Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·H D VentersK W Kelley
Nov 5, 2002·Nature Medicine·E CarroI Torres-Aleman
Apr 29, 2004·Journal of Neuroscience Research·Prashanth KenchappaKakoli Banerjee
Aug 10, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Xue-Zhao CaoWen-Fei Tan

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Citations

Jan 25, 2020·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Qiu-Xia XiaoYing Zhang
Jun 25, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Athena EnderamiHadi Darvishi-Khezri

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