Circulating Tumor Cell Assessment in Presumed Early Stage Non-Small Cell Lung Cancer Patients Treated with Stereotactic Body Radiation Therapy: A Prospective Pilot Study

International Journal of Radiation Oncology, Biology, Physics
Melissa A FrickCharles B Simone

Abstract

In patients treated with stereotactic body radiation therapy (SBRT) for presumed early stage non-small cell lung cancer (NSCLC), detection and monitoring of circulating tumor cells (CTCs) may be useful for assessing treatment response safely and noninvasively. No published reports of CTC trends in this patient population exist to date. Patients with clinically diagnosed stage I NSCLC treated with SBRT were eligible for this institutional review board-approved prospective clinical trial. Peripheral blood samples were assayed for CTCs via a green fluorescent protein-expressing adenoviral probe. CTC positivity was defined as 1.3 green fluorescent protein-positive cells/mL of collected blood. Samples were obtained before (pre-radiation therapy [RT]), during, and after SBRT (post-RT; months 1, 3, 6, 12, 18, and 24). SBRT was delivered in ≤5 fractions (median dose of 50 Gy in 12.5 Gy fractions) to a biological equivalent dose of ≥100 Gy in all cases. Forty-eight consecutive patients (T1a [73%], T1b [21%], and T2a [6%]) were enrolled. Median follow-up was 14.2 months. Twenty patients (42%) had a positive CTC level pre-RT, with a median CTC count of 4.2 CTCs per mL (interquartile range [IQR], 2.2-18.7). Of these 20 patients, 17 had eva...Continue Reading

Citations

Feb 23, 2019·Journal of Applied Clinical Medical Physics·Pranshu MohindraJay Burmeister
Oct 15, 2019·Expert Review of Molecular Diagnostics·Alessandro RussoChristian Rolfo
Jan 24, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Melissa A FrickGary D Kao
Feb 22, 2021·Seminars in Radiation Oncology·Samuel R Jean-BaptisteGary D Kao
May 19, 2021·Cold Spring Harbor Perspectives in Medicine·Humam KadaraKostyantyn Krysan

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