Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer

Biomarker Research
Wataru GotoMasaichi Ohira

Abstract

Circulating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is positively associated with CTC clusters in breast cancer. In this study, we investigated the correlation between plakoglobin expression and survival of breast cancer. We evaluated 121 breast cancer patients treated with neoadjuvant chemotherapy. Expression of plakoglobin was identified by immunohistochemical staining in the cell membrane. We also examined the relation between the expression of plakoglobin and E-cadherin, an epithelial-mesenchymal transition (EMT) marker. Patients with high plakoglobin expression had significantly worse distant-metastasis-free survival (DMFS) (P = 0.016, log rank). Plakoglobin expression had no correlation with pathological complete response rate (P = 0.627). On univariate analysis with respect to distant metastasis, high plakoglobin expression showed worse prognosis than low plakoglobin expression [P = 0.036, hazard ratio (HR) = 3.719]. Multivariate analysis found the same result (P = 0.013, HR = 5.052). In addition, there was a significant relationship between the expression of plakoglobin ...Continue Reading

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Citations

Jan 18, 2018·Scientific Reports·Arutha KulasingheChamindie Punyadeera
Aug 20, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Juan FangYing Liu
Mar 24, 2018·Cellular Oncology (Dordrecht)·Meysam YousefiAlihossein Saberi
Apr 16, 2020·International Journal of Molecular Sciences·Samuel AmintasEtienne Buscail
May 21, 2018·Journal of Cancer Research and Clinical Oncology·Koji TakadaMasaichi Ohira
Dec 20, 2018·Cancer Medicine·Arutha KulasingheChamindie Punyadeera
Dec 29, 2020·Journal of Advanced Research·Yanlin ChenYixuan Hou
Jan 31, 2021·Cell Division·Julia BonnetValérie Lobjois
Dec 20, 2020·International Journal of Molecular Sciences·Walter Tinganelli, Marco Durante

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Methods Mentioned

BETA
biopsy
dissection

Software Mentioned

JMP11

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