Circulating Tumor Cell Detection in Lung Cancer: But to What End?

Cancers
Véronique HofmanPaul Hofman

Abstract

The understanding of the natural history and biology of lung cancer has been enhanced by studies into circulating tumor cells (CTCs). Fundamental and translational research, as well as clinical trials in the characterization and behavior of these cells, have constantly contributed to improving understanding within the domain of thoracic oncology. However, the use of these CTCs as prognostic and predictive biomarkers has not been adopted to the same extent as circulating free DNA (cf-DNA) in plasma, in the daily practice of thoracic oncologists. However, recent technological advances have firmly put the detection and characterization of CTCs in thoracic oncology back on the agenda, and have opened up perspectives for their routine clinical use. This review discusses the major advances of using CTCs in the domain of thoracic oncology, as well as the envisaged short- and long-term prospects.

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Citations

Feb 6, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marius IliéUNKNOWN STALKLUNG01 Study Consortium Investigators
Feb 22, 2021·Seminars in Radiation Oncology·Samuel R Jean-BaptisteGary D Kao

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Methods Mentioned

BETA
biopsy
Xenografts
xenograft
RNAseq

Software Mentioned

NanoArrays

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