Circulating tumor cells and serum levels of MMP-2, MMP-9 and VEGF as markers of the metastatic process in patients with high risk of metastatic progression

Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Marketa SkerenovaPetra Tesařová

Abstract

Metastases are a severe complication in cancer patients and biomarkers predicting their progression are still lacking for specific groups of patients. HER2 positive breast cancer (HER2 BC) patients on trastuzumab therapy are at risk of the development of unpredictable and often fatal central nervous system (CNS) metastases and castration resistant prostate cancer (CRPC) patients urgently need a marker of disease progression during therapy. Proposed metastatic markers: circulating tumor cells (CTC), serum levels of matrix metalloproteinase 2 (MMP-2), 9 (MMP-9) and vascular endothelial growth factor (VEGF) were prospectively studied to confirm their utility in these two narrowly defined groups of cancer patients. The groups comprised 44 advanced HER2 BC, 24 CRPC patients and 42 healthy controls. An immunomagnetic separation method followed by PCR and electrophoretic detection (AdnaGen, Germany) were used for CTC determination. Serum marker levels were determined by the ELISAs (R&D System, USA). MMP-2 serum level was significantly higher in HER2 BC patients who developed CNS metastases, especially if there were also bone metastases. CTCs were a negative predictive marker for overall survival in HER2 BC patients. MMP-9 serum level ...Continue Reading

References

Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
Oct 12, 2000·Nature Cell Biology·G BergersD Hanahan
Oct 2, 2001·Cancer Letters·S M Sheen-ChenW J Chen
Jan 29, 2003·Angiogenesis·A LarssonH Ericson
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sirpa LeppäInkeri Elomaa
Aug 20, 2004·The New England Journal of Medicine·Massimo CristofanilliDaniel F Hayes
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy U LinEric P Winer
Dec 9, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J Hicklin, Lee M Ellis
May 24, 2005·Biochimica Et Biophysica Acta·Mikael Björklund, Erkki Koivunen
Sep 15, 2005·Clinical & Experimental Metastasis·Odete MendesGeorge Stoica
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
Dec 22, 2006·Nature Clinical Practice. Oncology·Martin J Slade, R Charles Coombes
Feb 28, 2007·Critical Reviews in Oncology/hematology·Robert Roskoski
Oct 9, 2007·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Nov 18, 2008·Matrix Biology : Journal of the International Society for Matrix Biology·Beverly Z PackardKenneth M Yamada
Jul 16, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U De GiorgiM Cristofanilli
Nov 6, 2009·Journal of Cardiothoracic Surgery·Georgios T KarapanagiotidisChristos Papakonstantinou
Jan 13, 2010·Cell·Mi-Young KimJoan Massagué
Apr 20, 2010·Cardiovascular Research·David O Bates
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 14, 2011·Clinical Biochemistry·Suprava PatelAlpana Saxena
Aug 2, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Evi S Lianidou, Athina Markou
Dec 22, 2012·Cell Adhesion & Migration·Martine Perrot-Applanat, Melanie Di Benedetto
Jan 30, 2013·Journal of Cancer Research and Clinical Oncology·Mark ThalgottMargitta Retz
Dec 11, 2013·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Dec 29, 2013·Journal of Cancer Research and Clinical Oncology·Yinglong ZhangXiuchun Qiu
Jan 22, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·D SerpicoS Di Cosimo

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Citations

Jul 3, 2020·International Journal of Molecular Sciences·Francisca DiasRui Medeiros
Aug 15, 2018·Molecular Medicine Reports·Xiaobo HuiYanping Wang
Jun 7, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Roopali RoyMarsha A Moses
Mar 3, 2020·Journal of the Neurological Sciences·Pitchaya Wanleenuwat, Piotr Iwanowski
Aug 8, 2021·Cancers·Elena Díaz-GarcíaCarolina Cubillos-Zapata

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