Circulating tumor cells and their advances to promote cancer metastasis and relapse, with focus on glioblastoma multiforme

Experimental and Molecular Pathology
Dimitry A Chistiakov, Vladimir P Chekhonin

Abstract

In the late stages of their development, cancers can form metastases. Formation of metastases was found to be associated with the capacity of cancer cells to quit the tumor mass and journey through the circulation to distant organs. This cell population is called circulating tumor cells (CTCs). They exhibit several advanced properties such as epithelial-to-mesenchymal transition (EMT) and dormancy that are essential for supporting their survival in the bloodstream, radio- and chemoresistance, their escape from the anti-cancer immune response, and metastasis initiation. CTCs, and especially dormant tumor cells, are responsible for post-surgery tumor recurrence. CTCs were detected in the blood of patients affected with glioblastoma multiforme (GBM)-the most frequent, invasive, and deadly neoplasm among primary brain tumors. The identification of glioblastoma CTCs might have a promising clinical potential for early tumor diagnosis and prognosis. A variety of CTC enrichment and detection techniques have been developed to date. For several epithelial cancers, especially for breast carcinoma, a prognostic value of CTCs was reported. Similar efforts should be performed for GBM to evaluate clinical the significance of CTCs.

Citations

Feb 10, 2019·International Journal of Molecular Sciences·Miguel QuintanillaEster Martín-Villar
Mar 8, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Rocio I R MaciasJesus M Banales
Sep 4, 2020·Micromachines·Lexi L CrowellTayloria N G Adams
Nov 4, 2020·Expert Review of Molecular Diagnostics·Sayuri HerathArutha Kulasinghe
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sahar SafaeeBehzad Baradaran
May 1, 2021·International Journal of Molecular Sciences·Severa BundaGelareh Zadeh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

International Journal of Cancer. Journal International Du Cancer
Kjersti TjensvollRune Smaaland
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
C Van BerckelaerP A van Dam
© 2022 Meta ULC. All rights reserved