Circulating tumor cells as a new predictive and prognostic factor in patients with small cell lung cancer

Journal of Cancer
Pei-Pei WangYong Wu

Abstract

Background: Small cell lung cancer (SCLC) is the most malignant type of lung cancer characterized by rapid progression, early metastasis and recurrence. In recent years, circulating tumor cells (CTCs) were found to play an important role in tumor invasion, metastasis, recurrence and prognosis. Methods: CTCs were detected in 138 patients with newly diagnosed SCLC from January 2012 to December 2018. Nomogram prediction models were constructed based on prognostic factors screened by multivariate Cox regression analysis and the risk stratification of SCLC patients were performed on basis of nomogram points. A total of 108 patients from January 2012 to December 2016 were assigned to a training group, and 30 patients from January 2017 to December 2018 were included into the validation group for nomogram analysis. This study was approved by ethics committee of Guangzhou First People's Hospital and all subjects provided informed consent. Results: The number of CTCs was associated with age, lymph node metastasis (N), distant metastasis (M), TNM staging, and NSE. The high number of CTC predicted adverse prognosis, and the AUC of time-dependent ROC curve was all high than 0.5. In the training group, after multivariate COX regression scree...Continue Reading

Citations

Oct 10, 2020·Technology in Cancer Research & Treatment·Kunpeng DuJiqiang Li
Jan 13, 2021·Biomedicines·Patricia Mondelo-MacíaRoberto Díaz-Peña
Dec 3, 2020·Journal of Clinical Medicine·Guillaume HerbreteauJean-Louis Pujol

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