Circulating Tumor Cells as a Tool of Minimal Residual Disease Can Predict Lung Cancer Recurrence: A longitudinal, Prospective Trial

Diagnostics
Ching-Yang WuJason Chia-Hsun Hsieh

Abstract

The role of circulating tumor cells (CTCs) for predicting the recurrence of cancer in lung cancer patients after surgery remains unclear. A negatively selected protocol of CTC identification was applied. For all the enrolled patients, CTC testing was performed before and after surgery on the operation day (day 0), postoperative day 1, and day 3. The daily decline and trend of CTCs were analyzed to correlate with cancer relapse. The mixed model repeated measures (MMRM) adjusted by cancer characteristics was applied for statistical significance. Fifty patients with lung mass undergoing surgery were enrolled. Among 41 primary lung cancers, 26 (63.4%) were pathological stage Tis and I. A total of 200 CTC tests were performed. MMRM analysis indicated that surgery could contribute to a CTC decline after surgery in all patients with statistical significance (p = 0.0005). The daily decrease of CTCs was statistically different between patients with and without recurrence (p = 0.0068). An early rebound of CTC counts on postoperative days 1 and 3 was associated with recurrence months later. CTC testing can potentially serve as a tool for minimal residual disease detection in early-staged lung cancer after curative surgery.

References

Dec 1, 1987·Cancer·K B NolopJ M Hughes
Jan 23, 1999·American Journal of Human Genetics·Y M LoN M Hjelm
Jul 27, 2000·The New England Journal of Medicine·R M PietermanH J Groen
Nov 18, 2006·Cell·Gaorav P Gupta, Joan Massagué
Nov 21, 2007·Nature·Catherine M KoebelRobert D Schreiber
Jul 4, 2008·The New England Journal of Medicine·Shyamala MaheswaranDaniel A Haber
May 26, 2009·The Annals of Thoracic Surgery·Yoshitomo OkumuraSeiki Hasegawa
Nov 6, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fumihiro TanakaSeiki Hasegawa
Dec 29, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·David P CarboneThao P Dang
May 18, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sun Och YoonChul-Woo Kim
Dec 15, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yang-Hao YuChih-Yi Chen
Dec 17, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yung-Hung LuoYuh-Min Chen
Jan 3, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·John D O'FlahertyKenneth J O'Byrne
Dec 5, 2012·Acta Cytologica·Rachel YoungPhilippe Vielh
Dec 3, 2014·Critical Reviews in Oncology/hematology·Annette TognelaPaul de Souza
Jul 27, 2015·Journal of Cancer Research and Clinical Oncology·Mario MascalchiMario Pazzagli
Aug 13, 2015·Medicine·Ching-Feng WuWen-Chi Chou
Nov 29, 2015·The Journal of Thoracic and Cardiovascular Surgery·Rishindra M ReddySunitha Nagrath
Dec 17, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lindsey A TorreAhmedin Jemal
Feb 3, 2016·Clinical Lung Cancer·Dariusz Adam DziedzicUNKNOWN Polish Lung Cancer Study Group (PLCSG)
Feb 24, 2016·Molecular Oncology·Takaaki MasudaKoshi Mimori
May 18, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lawrence H SchwartzLesley Seymour
Jul 30, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Phil A J CrosbieCaroline Dive
Aug 17, 2016·International Journal of Molecular Sciences·Alexandra C KölblUlrich Andergassen
Jul 1, 2017·Targeted Oncology·Justin D Lathia, Huiping Liu
Dec 7, 2017·Cancer Discovery·Iñaki Comino-Mendez, Nicholas Turner
Jul 23, 2018·The Annals of Thoracic Surgery·Lucas W ThornbladeFarhood Farjah
Sep 13, 2018·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Juliana BuenoJonathan H Chung
Feb 10, 2019·Trends in Pharmacological Sciences·Gabriele De RubisMary Bebawy

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Methods Mentioned

BETA
biopsy
blood drawing
dissection
flow cytometry

Clinical Trials Mentioned

NCT03724500

Software Mentioned

SPSS

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