Circulating Tumor Cells as an Independent Predictor of Survival in Advanced Gastric Cancer

Annals of Surgical Oncology
H OkabeY Sakai

Abstract

When the indication for surgery of highly advanced gastric cancer is considered, careful selection of the patients is important. In addition to tumor-node-metastasis factors and peritoneal lavage cytology (CY), which are important predictors of prognosis, detection of circulating tumor cells (CTCs) could be another potential marker. This study prospectively evaluated CTCs using a semi-automated immunomagnetic separation system (CellSearch) for 136 patients with advanced gastric cancer to determine the frequency of CTC positivity. For 123 patients who also had their CY evaluated, the significance of both CTC and CY, was investigated as a potential biomarker to predict progression-free survival (PFS) or to monitor the therapeutic effect. In 25 patients (18.4 %), CTCs were positive. Positive CTC counts were more common for tumors with diffuse histologic type and distant metastasis. The PFS of CTC-positive patients was significantly shorter than that of CTC-negative patients (hazard ratio 2.03; P = 0.016). A multivariate analysis of 123 patients showed that CTC and CY as well as performance status and macroscopic distant metastasis were independent factors for PFS. When both CTC and CY were converted to negative values by therapeut...Continue Reading

References

Aug 20, 2004·The New England Journal of Medicine·Massimo CristofanilliDaniel F Hayes
Jun 13, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Seiji SatohYoshiharu Sakai
Jul 11, 2006·The New England Journal of Medicine·David Cunningham MAGIC Trial Participants
Jan 24, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J SastreE Díaz-Rubio
Sep 4, 2008·Annals of Surgical Oncology·Kunihiko HiraiwaYuko Kitagawa
Aug 27, 2010·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·V PaleriR G Wight
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Jun 15, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Seiji SatohYoshiharu Sakai
Apr 25, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yasuhiro KoderaMichitaka Fujiwara
May 15, 2013·Journal of the National Comprehensive Cancer Network : JNCCN·Jaffer A AjaniUNKNOWN National Comprehensive Cancer Network
May 8, 2014·International Journal of Cancer. Journal International Du Cancer·Xuanzhang HuangZhenning Wang

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Citations

Feb 24, 2016·Molecular Oncology·Takaaki MasudaKoshi Mimori
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bo ChenLian-Guo Shi
Aug 18, 2016·Helicobacter·Marino VeneritoPeter Malfertheiner
Nov 1, 2016·Expert Review of Molecular Diagnostics·J F SwennenhuisL W M M Terstappen
Dec 6, 2017·Expert Review of Anticancer Therapy·Anthony LopezJaffer A Ajani
Apr 12, 2019·Gut and Liver·Moon Won LeeSu Jin Park
Mar 5, 2016·World Journal of Gastroenterology : WJG·Jing ZhongLiang-Jing Wang
Mar 19, 2020·Cancers·Phung Thanh HuongHung N Luu
Mar 31, 2018·Oncotarget·Camila Tavares Uchôa GuimarãesDanielle Queiroz Calcagno
Dec 29, 2016·World Journal of Gastroenterology : WJG·Hiroaki ItoHaruhiro Inoue
Nov 25, 2017·Cancer Biomarkers : Section a of Disease Markers·Runhua FengZhenggang Zhu
Dec 3, 2016·Langenbeck's Archives of Surgery·Hisahiro HosogiYoshiharu Sakai
Apr 25, 2017·Annals of Gastroenterological Surgery·Takaaki ArigamiShoji Natsugoe
Mar 31, 2017·Molecular and Clinical Oncology·Yongping LiuChangsong Zhang
May 26, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Gun Jung Youn, Woo Chul Chung
May 6, 2020·Annals of Surgical Oncology·Nobuhito NittaKatsuhiko Uesaka
Mar 23, 2018·Cancer Biomarkers : Section a of Disease Markers·Runhua FengZhenggang Zhu
Mar 2, 2019·Acta Cytologica·Sara Abalde-CelaLorena Diéguez

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