Circulating tumor cells as Trojan Horse for understanding, preventing, and treating cancer: a critical appraisal.

Cellular and Molecular Life Sciences : CMLS
Alexios-Fotios A MentisAthanasios G Papavassiliou

Abstract

Circulating tumor cells (CTCs) are regarded as harbingers of metastases. Their ability to predict response to therapy, relapse, and resistance to treatment has proposed their value as putative diagnostic and prognostic indicators. CTCs represent one of the zeniths of cancer evolution in terms of cell survival; however, the triggers of CTC generation, the identification of potentially metastatic CTCs, and the mechanisms contributing to their heterogeneity and aggressiveness represent issues not yet fully deciphered. Thus, prior to enabling liquid biopsy applications to reach clinical prime time, understanding how the above mechanistic information can be applied to improve treatment decisions is a key challenge. Here, we provide our perspective on how CTCs can provide mechanistic insights into tumor pathogenesis, as well as on CTC clinical value. In doing so, we aim to (a) describe how CTCs disseminate from the primary tumor, and their link to epithelial-mesenchymal transition (EMT); (b) trace the route of CTCs through the circulation, focusing on tumor self-seeding and the possibility of tertiary metastasis; (c) describe possible mechanisms underlying the enhanced metastatic potential of CTCs; (d) discuss how CTC could provide f...Continue Reading

References

May 20, 2000·Annals of the New York Academy of Sciences·M StrounP Anker
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Oleg Schmidt-KittlerChristoph A Klein
Dec 26, 2006·Human Pathology·Dena MarrinucciPeter Kuhn
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine RiethdorfKlaus Pantel
Dec 7, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel C DanilaHoward I Scher
Jul 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven J CohenNeal J Meropol
Mar 24, 2009·European Journal of Radiology·Aaron M Rutman, Michael D Kuo
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri, Robert A Weinberg
Jul 22, 2009·Cancer Letters·Panayiotis A TheodoropoulosVassilis Georgoulias
Jan 13, 2010·Cell·Mi-Young KimJoan Massagué
Jan 30, 2010·Journal of Oncology·Dena MarrinucciPeter Kuhn
Sep 25, 2010·Breast Cancer Research : BCR·Laurien D C HoefnagelPaul J van Diest
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Dan G DudaRakesh K Jain
Feb 9, 2011·The Journal of Cell Biology·Min YuDaniel A Haber
Apr 28, 2011·Nature Reviews. Clinical Oncology·Elizabeth ComenJoan Massagué
Sep 14, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jian Q Yu, Massimo Cristofanilli
Dec 6, 2011·Cancer Research·Eleonora DondossolaAngelo Corti
Mar 13, 2012·Seminars in Cancer Biology·Neha TiwariGerhard Christofori
Apr 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elizabeth A PunnooseMark R Lackner
Jul 18, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Xue-Lei MaYu-Quan Wei
Aug 22, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Liling ZhangKlaus Pantel
Feb 22, 2013·Journal of the Royal Society, Interface·Jacob G ScottPhilip Gerlee
Jun 4, 2013·Nature Cell Biology·Cyrus M GhajarMina J Bissell
Oct 18, 2013·The New England Journal of Medicine·Cheryl Bettigole
Jan 15, 2014·Blood·Sameer A ParikhTait D Shanafelt
Feb 14, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Xiaosai YaoJ Christopher Love
Feb 25, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xuelei MaLei Liu
Apr 12, 2014·Biochimica Et Biophysica Acta·Anna HaegerPeter Friedl
Aug 19, 2014·World Journal of Gastroenterology : WJG·Ulrich BorkJürgen Weitz
Sep 4, 2014·The New England Journal of Medicine·Emmanuel S AntonarakisJun Luo
Sep 23, 2014·American Journal of Clinical Oncology·Richard L HeskethRahmi Oklu
Dec 18, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Arun SatelliShulin Li
Mar 10, 2015·Computational and Structural Biotechnology Journal·Konstantina KourouDimitrios I Fotiadis
Mar 25, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Howard I ScherJohann S de Bono

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Citations

Sep 29, 2020·Frontiers in Cell and Developmental Biology·Theresa D AhrensMette Ø Agerbæk
Nov 17, 2020·Frontiers in Immunology·Antonella SistiguRuggero De Maria
Apr 4, 2021·Cancers·Yelyzaveta ShlyakhtinaMaximiliano M Portal
Jun 3, 2021·Journal of Personalized Medicine·Miriam González-CondeClotilde Costa
Jul 22, 2021·Current Cancer Drug Targets·Snezhanna Olegovna GeningTatyana Petrovna Gening

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Methods Mentioned

BETA
biopsy
xenograft
flow cytometry
single-cell sequencing
genotyping
biopsies
acetylation
imaging techniques

Software Mentioned

UROSEEK
CellSearch
Epispot
PapSEEK
CancerSEEK

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