Circulating tumor cells in breast cancer

Molecular Oncology
Francois-Clement BidardJean-Yves Pierga

Abstract

Over the past decade, technically reliable circulating tumor cell (CTC) detection methods allowed the collection of large datasets of CTC counts in cancer patients. These data can be used either as a dynamic prognostic biomarker or as tumor material for "liquid biopsy". Breast cancer appears to be the cancer type in which CTC have been the most extensively studied so far, with level-of-evidence-1 studies supporting the clinical validity of CTC count in both early and metastatic stage. This review summarizes and discusses the clinical results obtained in breast cancer patients, the issues faced by the molecular characterization of CTC and the biological findings about cancer biology and metastasis that were obtained from CTC.

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Methods Mentioned

BETA
biopsy
xenografts

Clinical Trials Mentioned

NCT01548677
NCT01349842
NCT01710605
NCT01619111
NCT01975142

Software Mentioned

CellSearch
Adnastest
Adnatest
TREAT
SUCCESS

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