Circulating tumor cells in clinical research and monitoring patients with colorectal cancer

Oncotarget
Claudia BurzIulia Lupan

Abstract

Colorectal cancer remains a frequent disease to which screening and target therapy exist, but despite this is still marked by a high mortality rate. Even though radical surgery may be performed in many cases, patients relapse with metastatic disease. Circulating tumor cells were incriminated for tumor recurrence, that's why vigorous research started on their field. Owning prognostic and predictive value, it was revealed their usefulness in disease monitoring. Moreover, they may serve as liquid biopsies for genetic tests in cases where tissue biopsy is contraindicated or cannot be performed. In spite of these advantages, they were not included in clinical guidelines, despite CellSearch and many other detection methods were developed to ease the identification of circulating tumor cells. This review highlights the implication of circulating tumor cells in metastasis cascade, intrinsic tumor cells mechanisms and correlations with clinical parameters along with their utility for medical practice and detection techniques.

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Citations

Nov 9, 2018·Expert Review of Molecular Diagnostics·Theresa L Whiteside
Apr 5, 2019·Expert Review of Molecular Diagnostics·Claudia BurzAndreea Pricopie
Oct 31, 2019·Clinical and Translational Gastroenterology·Wen-Sy TsaiAshish Nimgaonkar
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Aug 8, 2018·International Journal of Oncology·Alessia FinottiRoberto Gambari
Oct 24, 2020·International Journal of Molecular Sciences·Faysal Bin HamidAlfred King-Yin Lam
May 20, 2021·Lab on a Chip·Hedieh FallahiNam-Trung Nguyen

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Methods Mentioned

BETA
imaging techniques
biopsies
xenografts
surgical resection
flow cytometry
biopsy
PCR

Software Mentioned

AdnaTest
Epic
CellSearch
CelleSieve
CyteFinder

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