PMID: 16507408Mar 2, 2006Paper

Circulating tumor cells in patients with breast cancer: possible predictor of micro-metastasis in bone marrow but not in sentinel lymph nodes

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Li ZhuLouis W C Chow

Abstract

Blood and lymphatic circulation are the major routes during metastatic spread of breast cancer cells. Despite the predictive and prognostic value of bone marrow (BM) micro-metastasis, repeated and frequent BM aspirations may not be easily accepted by patients. We try to establish the role of circulating tumor cells as a predictor for micro-metastasis in BM and sentinel lymph node (SLN) as well as to identify the association between micro-metastasis in blood and lymphatic circulation. We prospectively studied 47 breast cancer patients without overt metastasis. Bilateral BM samples and blood samples were obtained before surgery and subsequently handled using magnetic-activated cell separation (MACS) followed by immunocytochemistry (ICC). SLN was examined by hematoxylin and eosin (H and E) staining and ICC. Blood and BM micro-metastasis were detected in 16 (35%) and 25 (54%) of 47 patients. SLN micro-metastasis were detected in 13 (27.7%) and 22 (46.8%) patients using H and E and ICC, respectively. All the patients with circulating tumor cells had micro-metastasis in BM, whereas 9 of 25 (36%) patients with micro-metastasis in BM had no circulating tumor cells (P < 0.001). On the other hand, there is no correlation between circulat...Continue Reading

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Citations

Jan 22, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Mitsuru Futakuchi, Rakesh K Singh
Dec 17, 2009·Future Oncology·Vincent Vinh-HungGabriel N Hortobagyi
Mar 1, 2011·Radiology and Oncology·Sara Prijic, Gregor Sersa
Oct 9, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li ZhuW C Chow Louis

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