Circulating tumor cells: the substrate of personalized medicine?

Frontiers in Oncology
Bryan T GreeneMichael R King

Abstract

Circulating tumor cells (CTCs) are believed to be responsible for the development of metastatic disease. Over the last several years there has been a great interest in understanding the biology of CTCs to understand metastasis, as well as for the development of companion diagnostics to predict patient response to anti-cancer targeted therapies. Understanding CTC biology requires innovative technologies for the isolation of these rare cells. Here we review several methods for the detection, capture, and analysis of CTCs and also provide insight on improvements for CTC capture amenable to cellular therapy applications.

Citations

Aug 27, 2013·Cancer Letters·Andrew D HughesMichael R King
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Biao HuangChangren Zhou
Jan 31, 2017·Journal of the American Chemical Society·Myoung-Hwan ParkPaula T Hammond
Jan 26, 2017·In Vitro Cellular & Developmental Biology. Animal·Melanie ArulSwee Hung Cheah
Mar 22, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P K GroverJ E Hardingham
Mar 15, 2018·Annual Review of Biomedical Engineering·Eric LinMichael R King
Jun 21, 2017·Journal of Translational Medicine·Michele GraciottiLana Kandalaft
Jan 18, 2013·New Journal of Physics·Michael J Mitchell, Michael R King
Aug 15, 2017·Cellular and Molecular Bioengineering·Zhenjiang Zhang, Michael R King
Jan 9, 2019·Frontiers in Bioengineering and Biotechnology·Sena YamanH Cumhur Tekin
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Theresa D AhrensMette Ø Agerbæk
Jun 13, 2015·Cancer Control : Journal of the Moffitt Cancer Center·Gisela CaceresAnthony M Magliocco
Jan 31, 2013·Biomacromolecules·Christa L Modery-PawlowskiAnirban Sen Gupta

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Methods Mentioned

BETA
flow cytometry
chip
leukapheresis
fluorescence activated cell sorting
FACS

Software Mentioned

MagSweeper
CellSearch

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