PMID: 6978962Jan 1, 1982Paper

Circulating vitamin D metabolite concentrations in childhood renal diseases

Kidney International
R W ChesneyH F DeLuca

Abstract

Vitamin D metabolites were measured in children, untreated with glucocorticoids, who had renal disease. Two groups were defined in relation to endogenous creatinine clearance values: those with impaired clearance , 0 to 48 ml/min per 1.73 m2; and those with unimpaired clearance, 75 to 150 ml/min per 1.73 m2. Serum 1.25(OH)2D was 16 +/- (SD) 12 pg/ml in impaired patients (N=24) and 48 +/- 16 pg/ml in unimpaired patients (N=18). The latter level is not different from healthy childhood controls (43 +/- 12 pg/ml; N=194). Serum samples of 25(OH)D2 and D3 were comparable in each group and not different from control values of 33.2 +/- 10.3 ng/ml. Serum 24,25(OH)2D was 0.6 +/- (SD) 0.14 ng/ml in patients with a clearance of less than 13 ml/min per 1.73 m2, 1.39 +/- 0.54 ng/ml in those with a clearance of 18 to 48 ml/min per 1.73 m2, and 152 +/- 0.91 ng/ml in patients without an impairment of clearance. Only patients with the lowest clearance had values different from control values of 1.70 +/- 0.57 ng/ml. In our study we suggest that a significant reduction in 24,25(OH)2D and 1,25(OH)2D are found at low clearance values in children with tubulointerstitial disease. Our study further suggests that a reduction in renal tubular mass is imp...Continue Reading

References

Feb 2, 1978·The New England Journal of Medicine·R W ChesneyH F DeLuca
Dec 1, 1978·Clinical Science and Molecular Medicine. Supplement·C M TaylorJ A Kanis
Jul 15, 1979·The Biochemical Journal·R M ShepardH F DeLuca
Aug 1, 1977·Archives of Biochemistry and Biophysics·J G HaddadT J Hahn
Jan 1, 1974·Nephron·G OffermannK Schaefer
Jan 1, 1980·Contributions to Nephrology·Y OguraI Tsukui
Feb 1, 1980·American Journal of Diseases of Children·R W ChesneyH F DeLuca
Aug 1, 1980·The Journal of Pediatrics·M E NormanH Rasmussen

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Citations

Apr 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·O Mehls, I B Salusky
Oct 1, 1988·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A Taylor, M E Norman
Dec 1, 1988·Archives of Disease in Childhood·R Steinherz
Nov 1, 2002·Pediatric Research·Russell W Chesney
Dec 1, 1985·The American Journal of the Medical Sciences·H M Cushner, N D Adams
Aug 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·I B SaluskyJ W Coburn
Apr 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R W ChesneyA C Alfrey
Feb 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C H HsuB L Buchsbaum
Sep 1, 1995·Kidney International·I B Salusky, W G Goodman
Mar 1, 1985·Kidney International·L WilsonF Llach
Nov 1, 1988·Kidney International·K SatomuraH F DeLuca
Jun 1, 1988·Kidney International·D A Feinfeld, L M Sherwood
May 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F Llach
May 2, 2002·Kidney International. Supplement·Eduardo SlatopolskyAlex J Brown
Jun 1, 1991·Clinical Pediatrics·J D HannaJ C Chan
May 29, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Orlando M Gutiérrez
Oct 1, 1989·Current Problems in Pediatrics·G Kainer, J C Chan
Jul 1, 1983·The Journal of Pediatrics·J F Rosen, R W Chesney

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