Circulating vitamin E levels and Alzheimer's disease: a Mendelian randomization study

Neurobiology of Aging
Guiyou LiuQinghua Jiang

Abstract

Alzheimer's disease (AD) is the leading cause of dementia in older adults. It is more than 50 years since vitamin E was recognized as critical for optimal neurological health. Clinical studies have yielded inconsistent findings on the effect of vitamin E on AD risk. Thus, it remains unclear whether vitamin E levels are genetically associated with AD risk. We performed a Mendelian randomization study to investigate association of circulating vitamin E levels with AD using large-scale vitamin E genome-wide association study data set (N = 7781 individuals of European descent) and AD genome-wide association study data set (N = 54,162 individuals [including 17,008 AD cases and 37,154 controls of European descent]). Mendelian randomization-Egger intercept test showed no significant pleiotropy (β = -0.113; p = 0.296). Inverse-variance weighted (odds ratio = 0.96, 95% confidence interval: 0.47-1.94, p = 0.936) and weighted median analyses (odds ratio = 1.13, 95% confidence interval: 0.35-3.69, p = 0.836) showed no significant association between vitamin E and AD. Together with previous literature, this suggests that vitamin E supplementation may not forestall AD in the general population.

Citations

Feb 20, 2019·International Journal of Molecular Sciences·Ana LloretAngeles Lloret
Sep 26, 2019·Current Gene Therapy·He ZhuangShu-Lin Liu
Sep 25, 2019·Current Gene Therapy·Tianyi ZhaoYadong Wang
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Mar 3, 2020·Journal of Alzheimer's Disease : JAD·Haihua ZhangGuiyou Liu
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Aug 8, 2020·Frontiers in Genetics·Tao WangBao-Liang Sun
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Nov 25, 2019·The Lancet. Psychiatry·Rebecca CarnegieRichard M Martin
May 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jing-Yi SunGuiyou Liu

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