PMID: 43657Jan 1, 1979

Circulatory and metabolic effects of acute beta 1-blockade in severe pre-eclampsia

Acta Obstetricia Et Gynecologica Scandinavica
N O LunellH Aström


Five mg of a beta 1-adrenoceptor antagonist (atenolol) was given i.v. to 5 women with severe pre-eclampsia in the 3rd trimester of pregnancy. There was a significant decrease of both mean systolic blood pressure, from 171 to 155 mm Hg, and mean diastolic blood pressure, from 116 to 107 mm Hg. The mean maternal heart rate decreased significantly from 90 to 74 and mean fetal heart rate significantly from 145 to 138 beats per min. There were no significant changes in the plasma levels of cyclic AMP, insulin, glucose, free fatty acids, 3-hydroxy-butyrate or glycerol.


Jan 1, 1983·European Journal of Clinical Pharmacology·S HögstedtA Rane
Apr 1, 1992·American Heart Journal·M BrodskyM Sada
Nov 1, 1981·British Journal of Clinical Pharmacology·K J ThorleyJ M Cruickshank
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·N O LunellJ Wager

Related Concepts

Cyclic AMP, (R)-Isomer
Adrenergic beta-Antagonists
Blood Glucose
Diastolic Blood Pressure
Nonesterified Fatty Acids
Fetal Heart
Fetal Structures
Pulse Rate

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