PMID: 9428621Jan 15, 1998Paper

Circulatory and myocardial effects of endothelin

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
B K KrämerG A Riegger

Abstract

The endothelin peptide family consists of the 21 amino acid isoforms endothelin-1, endothelin-2, endothelin-3, and sarafotoxin (a snake venom). Endothelin-1 has been isolated from the supernatant of endothelial cells and has subsequently been shown to be the most potent vasoconstrictor known to date and to be positively inotropic. This review summarizes some of the current literature pertaining to circulatory and myocardial effects of endothelins. Exogenously administered endothelin-1 has been demonstrated to increase peripheral resistance and blood pressure in a dose-dependent manner. However, during the first minutes of intravenous administration endothelins also decrease peripheral resistance and blood pressure, presumably due to the release of vasodilatory compounds such as nitric oxide, prostacyclin, and atrial natriuretic peptide. Endothelins appear to be involved in the pathogenesis of salt-dependent and renovascular animal models of experimental hypertension. Although endothelins appear to contribute to basal vascular tone, the role of endothelins in the pathophysiology of human hypertension remains unclear. In addition, a role has been suggested for endothelins in specific vascular lesions and inflammatory conditions (...Continue Reading

Citations

Jun 19, 2002·Clinical and Experimental Hypertension : CHE·Karla Carvajal, Guadalupe Baños
Jan 10, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ryan M FryerGlenn A Reinhart
Feb 24, 2001·The British Journal of Radiology·S D Oldroyd, S K Morcos
Apr 3, 2010·Pharmacological Reports : PR·Aleksandra PiechotaAnna Goraca
Nov 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B K KrämerM Schreiber
Aug 8, 2014·Cardiovascular Ultrasound·Monika KomarPiotr Podolec
Aug 16, 2001·Journal of Cardiothoracic and Vascular Anesthesia·A KumarJ E Parrillo
Sep 15, 2000·Clinics in Perinatology·S E Juul

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