Circumscribed palmo-plantar hypokeratosis: a disease of desquamation? Immunohistological study of five cases and literature review

Journal of the European Academy of Dermatology and Venereology : JEADV
J KanitakisM Faure

Abstract

Circumscribed palmoplantar hypokeratosis (CPH) is a recently recognized, rarely reported dermatosis that shows characteristic clinicopathological features; however, its pathogenesis remains unknown. The aim of this study was to get further insight into the pathogenesis of CPH. An immunohistological study was performed on five cases of CPH to investigate the expression of several epidermal proliferation and differentiation proteins, with emphasis on those involved in corneocyte desquamation [including corneodesmosin, kallikrein 5 and lympho-epithelial Kazal type inhibitor (LEKTI)]. In three of five cases, a decreased expression of LEKTI, corneodesmosin and filaggrin was found, along with an increased expression of kallikrein 5 and keratin 6. The expression of several other antigens (including involucrin, Ki67, p63, CD138/syndecan I, EGF-R) did not present a consistently different pattern as compared with the unaffected epidermis. The immunohistopathologic features of CPH suggest that an altered (accelerated) corneocyte desquamation process could be the main pathological mechanism underlying the development of lesions.

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Citations

Jan 20, 2016·Disease Markers·Ana Carolina B StefaniniEloiza H Tajara
Oct 18, 2015·International Journal of Dermatology·Hao GuoJiu-Hong Li
Feb 7, 2015·Journal of Dermatological Science·Yu-An CaoRoger L Kaspar
Oct 18, 2016·Clinical and Experimental Dermatology·H J Kim, M G Lee
Oct 8, 2016·Journal of Cutaneous Pathology·José Carlos CardosoCatherine M Stefanato
May 21, 2016·The American Journal of Dermatopathology·Alberto Ramos-GaribayFermín Jurado Santa-Cruz
Aug 11, 2012·The American Journal of Dermatopathology·Erica Riveiro-Falkenbach, José Luis Rodríguez-Peralto
Apr 9, 2013·The American Journal of Dermatopathology·Tatyana GroysmanMarisa F Baldassano
Jul 18, 2021·Clinics in Dermatology·Jean Kanitakis

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