Circumsporozoite protein gene diversity among temperate and tropical Plasmodium vivax isolates from Iran

Tropical Medicine & International Health : TM & IH
Sedigheh ZakeriG Snounou

Abstract

To date, there is no information on the genetic diversity of the circumsporozoite protein (CSP), a leading vaccine candidate, in Plasmodium vivax populations circulating in Iran. The gene for this protein, Pvcsp, was amplified from 374 P. vivax isolates collected in the temperate northern, and in the tropical southern endemic areas. PCR-RFLP analysis of the repeated central region revealed that the parasites collected in the northern area were almost exclusively of the VK210 type. Parasites collected in the south-eastern areas were of both VK210 and VK247 types. We detected VK210 parasite in 70.5% of the samples, VK247 parasites in 17.5% and mixed type infections in 12% of the isolates. Sequence analysis of 137 isolates obtained from both areas identified a total of 25 distinct genotypes. The degree of genetic diversity was generally higher for the tropical (21 genotypes) than the temperate (7 genotypes) P. vivax populations, a difference possibly reflecting the high cross-border exchanges between Afghanistan and Pakistan and southern Iran. Interestingly, all but two VK210 type isolates sequenced harboured a 36-bp post-repeat insert previously only observed in North Korea and China. This large-scale survey of parasite diversity...Continue Reading

References

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Citations

Mar 9, 2010·The American Journal of Tropical Medicine and Hygiene·Yien-Kyoung ChoiJung-Yeon Kim
Feb 15, 2011·The American Journal of Tropical Medicine and Hygiene·Miguel Ángel Hernández-MartínezSócrates Herrera
Feb 7, 2013·Experimental Parasitology·Saber GholizadehNavid Dinparast Djadid
Jan 10, 2008·Trends in Parasitology·Michelle L Gatton, Qin Cheng
Sep 1, 2009·Acta Tropica·Sedigheh ZakeriNavid Dinparast Djadid
Apr 3, 2007·Acta Tropica·Patricia D Santos-CimineraGerald V Quinnan
Dec 15, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Cara N Henry-HalldinPeter A Zimmerman
Jun 1, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Daibin ZhongBin Zheng
Aug 15, 2014·Frontiers in Immunology·Alyssa E Barry, Alicia Arnott
Mar 24, 2016·Revista Do Instituto De Medicina Tropical De São Paulo·Khojasteh Sharifi-SarasiabiLatif Gachkar
Jun 15, 2007·Memórias do Instituto Oswaldo Cruz·Wanessa Christina de Souza-NeirasRicardo Luiz Dantas Machado
Mar 23, 2017·Emerging Infectious Diseases·Eugenia LoGuiyun Yan
Mar 29, 2016·PLoS Neglected Tropical Diseases·Lindsey R FriedrichDavid Serre

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