Aug 14, 2019

CIRP downregulation renders cardiac cells prone to apoptosis in heart failure

Biochemical and Biophysical Research Communications
Minxiao ChenPeng Zhong

Abstract

Cold-inducible RNA binding protein (CIRP) is a stress protein which is involved in regulating multiple cellular processes. However, its role in pathological heart diseases is still unknown. Our current study was aimed at addressing the response and functional role of CIRP in heart failure. CIRP protein level was evaluated in heart samples from patients with heart failure and mice with post-myocardial infarction (post-MI). Cardiac-derived H9C2 cells were utilized to test the effects of CIRP deficiency on cell survival and apoptosis in response to H2O2 treatment. Reduced expression of cardiac CIRP was observed in patients with heart failure, mice with post-MI. In addition, knockdown of CIRP exacerbated cell apoptosis and cell death in response to H2O2 treatment, suggesting a protective role of CIRP in cell apoptosis induced by oxidative stress in the heart. Our findings suggest that altered expression of CIRP may be involved in the pathogenesis of heart failure and downregulation of CIRP may render cardiac cells prone to apoptosis in heart failure.

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Mentioned in this Paper

Study
Hydrogen Peroxide
Cellular Process
Pathogenesis
Gene Knockdown Techniques
Oxidative Stress
Myocardial Infarction
Cirp protein, rat
Heart Cell
Down-Regulation

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis