Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes.

Annals of Hepatology
J Clayborn BartonGordon D McLaren

Abstract

We sought to identify independent risk factors for cirrhosis in HFE p.C282Y homozygotes in a cross-sectional study. We evaluated 368 p.C282Y homozygotes who underwent liver biopsy and compared characteristics of those with and without cirrhosis. We performed multivariable logistic regression on cirrhosis with: age; sex; race/ethnicity; diabetes; blood pints/units donated voluntarily; erythrocyte pints/units received; iron supplement use; alcohol intake, g/d; body mass index, kg/m2; swollen/tender 2nd/3rd metacarpophalangeal joints; elevated alanine aminotransferase; elevated aspartate aminotransferase; steatosis/fatty liver; iron removed by phlebotomy, g; and GNPAT p.D519G positivity. Mean age of 368 participants (73.6% men) was 47 ± 13 (standard deviation) y. Cirrhosis was diagnosed in 86 participants (23.4%). Participants with cirrhosis had significantly greater mean age, proportion of men, diabetes prevalence, mean daily alcohol intake, prevalence of swollen/ tender 2nd/3rd metacarpophalangeal joints, mean serum ferritin, elevated alanine aminotransferase, elevated aspartate aminotransferase, and mean iron removed; and significantly fewer mean blood pints/units donated. GNPAT p.D519G positivity was detected in 82 of 188 part...Continue Reading

Citations

Mar 7, 2019·The American Journal of Gastroenterology·Amanda CheungMary E Rinella
May 15, 2019·Nutrients·Chang-Kyu Oh, Yuseok Moon
Jun 6, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anil PrabhuJohn D Ryan
Mar 7, 2021·Clinics and Research in Hepatology and Gastroenterology·Andree H KoopWilliam C Palmer
Mar 26, 2021·Frontiers in Genetics·Manuel CorpasEdmund Lehmann
May 25, 2021·Hepatology Communications·Kris V KowdleyPriya Handa

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