Cis-acting determinants of paramutation

Seminars in Cell & Developmental Biology
Iris HövelMaike Stam

Abstract

Paramutation is an epigenetic phenomenon whereby in trans communication between homologous sequences leads to meiotically heritable epigenetic changes at one of the alleles. Cis-acting determinants of paramutation are DNA sequences and associated epigenetic modifications that are required for paramutation. Here, we review how characteristics of the underlying DNA sequences determine whether paramutation can occur and how they affect the behavior displayed by the various paramutation phenomena. Paramutation is strongly associated with repeated sequences, especially tandemly repeated sequences. Cis-acting determinants consisting of repeated sequences are consistent with the involvement of RNA-directed DNA methylation (RdDM) in plants and the PIWI-interacting RNA (piRNA) pathway in animals. In the RdDM-based model, siRNAs produced by paramutagenic loci would reinforce the silenced state of paramutagenic loci in cis and initiate transcriptional silencing of paramutable loci in trans. In this review, we discuss how sequence characteristics and epigenetic modifications of cis-acting sequences can trigger the recruitment of silencing machineries.

References

Jul 1, 1993·The Plant Journal : for Cell and Molecular Biology·P MeyerI Niedenhof
Jul 12, 1996·Cell·R Aramayo, R L Metzenberg
Apr 4, 1997·The Journal of Biological Chemistry·I HatadaT Mukai
Apr 13, 1999·Molecular Cell·P van WestF Govers
Jul 8, 2000·The Plant Journal : for Cell and Molecular Biology·L V SidorenkoT Peterson
Feb 2, 2002·The EMBO Journal·Minoo RassoulzadeganFrançois Cuzin
Jul 18, 2002·Current Biology : CB·Xiaofeng Cao, Steven E Jacobsen
Nov 14, 2002·Annual Review of Genetics·Ian W Duncan
May 13, 2003·Nature Genetics·Herry HermanPaul D Soloway
Jul 9, 2003·Nature Genetics·Ortrun Mittelsten ScheidJerzy Paszkowski
Nov 1, 2003·Nature Genetics·Robert A Martienssen
Feb 28, 2004·Science·Simon W-L ChanSteven E Jacobsen
Jun 24, 2004·Nature Reviews. Genetics·Vicki L Chandler, Maike Stam
Jul 16, 2005·Genetics·Jay B HollickSusan E Parkinson
Aug 24, 2005·The Plant Journal : for Cell and Molecular Biology·Meenu KapoorHiroshi Takatsuji
May 26, 2006·Nature·Minoo RassoulzadeganFrançois Cuzin
Nov 16, 2006·PLoS Biology·Simon W-L ChanSteven E Jacobsen
Dec 19, 2006·Nature Reviews. Genetics·Shiv I S Grewal, Songtao Jia
Feb 27, 2007·Cell·Vicki L Chandler
Mar 17, 2007·Nature Reviews. Genetics·R Keith Slotkin, Robert Martienssen
Jun 15, 2007·The Plant Journal : for Cell and Molecular Biology·Jennifer HetzlOrtrun Mittelsten Scheid
Feb 26, 2008·Journal of Molecular Biology·Sebastian WorchDietmar Schlote
Sep 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kan NobutaBlake C Meyers
Nov 22, 2008·Science·John EidStephen Turner
Mar 3, 2009·Science·Karl F ErhardJay B Hollick
Apr 2, 2009·The Plant Cell·Marieke LouwersMaike Stam
Oct 13, 2009·Development·Valérie GrandjeanMinoo Rassoulzadegan
Nov 26, 2009·PLoS Genetics·Jennifer L StonakerJay B Hollick
Dec 1, 2009·Trends in Genetics : TIG·Catherine M Suter, David I K Martin
May 7, 2010·The Plant Journal : for Cell and Molecular Biology·Max HaringMaike Stam
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mario Arteaga-VazquezVicki L Chandler

❮ Previous
Next ❯

Citations

Nov 1, 2016·Nature Reviews. Genetics·Jay B Hollick
Aug 2, 2017·Journal of Genetics·Johannes Manjrekar

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.