Cis-acting effect of the IL1B C-31T polymorphism on IL-1 beta mRNA expression

Genes and Immunity
R KimuraT Ishida

Abstract

Since the effect of IL1B polymorphisms on IL-1beta production is still controversial, we selected two polymorphisms to test their cis-acting effect on IL-1beta mRNA expression by means of the allele-specific transcript quantification and the haplotype analysis. As for the C-31T polymorphism, we found that expression of the -31T allele was 2.2 times of the -31C allele. This higher transcription efficiency may correspond to the fact that C-31T is located in a TATA box. The other polymorphism, C+3954T, did not alter the levels of transcription. The use of the allele-specific transcript quantification enables us to exclude trans-acting effects of polymorphisms on the gene expression and contributes to understanding the roles of the IL1B polymorphisms in susceptibility to multifactorial diseases.

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Citations

Sep 1, 2005·Immunogenetics·M L MorenoJ C Bai
Apr 6, 2011·Journal of Molecular Neuroscience : MN·Paulina BorkowskaJan Kowalski
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