PMID: 375001Jan 16, 1979Paper

Cis-dominant regulatory mutations affecting the expression of GABA permease in Aspergillus nidulans

Molecular & General Genetics : MGG
C R BaileyH N Arst

Abstract

In Aspergillus nidulans expression of the gabA gene, the probable structural gene for the gamma-amino-n-butyrate (GABA) permease, is controlled by induction, via the intA gene, ammonium repression, mediated by the areA gene, and probably carbon catabolite repression. Regulatory mutations, tightly linked to gabA, were selected by reverting an areAr-2 strain on GABA as nitrogen source. These mutations, gabI-1, gabI-2, and gabI-3 result in increased gabA expression and are cis-dominant in their effects on the gabA gene. Mapping data show that the regulatory mutations map on one side of all gabA- alleles tested.

References

Feb 21, 1975·European Journal of Biochemistry·C Bailey, H N Arst
Feb 28, 1977·Molecular & General Genetics : MGG·H N Arst
Jul 15, 1976·Nature·H N Arst
Sep 29, 1975·Molecular & General Genetics : MGG·J R Kinghorn, J A Pateman
Nov 2, 1973·Molecular & General Genetics : MGG·H N Arst, D J Cove
Aug 16, 1974·Nature·E Bartnik, P Weglenski
Jan 1, 1953·Advances in Genetics·G PONTECORVOA W J BUFTON

❮ Previous
Next ❯

Citations

May 1, 1989·Molecular & General Genetics : MGG·I B RichardsonM J Hynes
May 1, 1986·Molecular & General Genetics : MGG·M X CaddickH N Arst
May 1, 1984·Current Genetics·N M Al TahoC Scazzocchio
Nov 26, 2003·Journal of Molecular Biology·Javier Fernández-MartínezEduardo A Espeso
Oct 1, 1980·Genetical Research·C R BaileyH A Penfold
Apr 25, 2000·Molecular and Cellular Biology·E A Espeso, H N Arst
Sep 5, 2002·Microbiology and Molecular Biology Reviews : MMBR·Miguel A Peñalva, Herbert N Arst
Oct 19, 2004·Annual Review of Microbiology·Miguel A Peñalva, Herbert N Arst
Jul 1, 2004·Molecular Plant Pathology·María D García-Pedrajas, Scott E Gold
Jun 26, 2021·Frontiers in Microbiology·Xinhong PengXiliang Jiang
Mar 15, 2006·Fungal Genetics and Biology : FG & B·Z ErpapazoglouV Sophianopoulou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.