journal cover

Cis-Regulatory Accessibility Directs Muller Glial Development and Regenerative Capacity

bioRxiv

Sep 3, 2019

Thomas Andrew RehKristen E Cox

Get paper from

Abstract

Diseases of the retina can lead to losses in neurons and vision. Although the mammalian retina has no inherent regenerative capabilities, fish robustly regenerate from Muller glia (MG). Driving expression of Ascl1 in adult mouse MG stimulates neurogenesis; however, Ascl1-expressing MG p...read more

Mentioned in this Paper

DNA
Glioma
Laboratory mice
Myasthenia Gravis
Nerve Regeneration
Neuroglia
Neurons
Photoreceptors
Natural Regeneration
Retina
4
3
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Neuroregeneration (Preprints)

Neuroregeneration is a natural process that occurs in response to neuronal injury. Understanding the mechanisms behind neuroregeneration could improve therapies for both neuronal injury and potentially neurodegenerative disorders. Discover the latest preprints on neuroregeneration here.

Gene Regulatory Networks

Gene regulatory networks are comprised of molecular regulators that interact with each other and other factors in a cell to regulate and modulate gene expression. Here is the latest research.

Neurotoxicity, Inflammation & Neuroprotection

The end result of the inflammatory process, neurotoxicity and/or neuroprotection, is a function of the fine balance between the two cellular systems, i.e., of the complex signaling relationships between anti-inflammatory neuroprotective factors (neurotrophins and other chemical mediators) and proinflammatory neurotoxic factors (tnf, free radicals, certain cytokines, etc). Here are the latest discoveries pertaining to neurotoxicity, inflammation and neuroprotection.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Neuroregeneration

Neuroregeneration is the growth or repair of neural cells and tissues following damage or injury. Discover the latest research on neuroregeneration here.

Genetic Engineering to Program Cells

Genetic engineering is a process that alters the genetic structure of an organism by removing or introducing DNA. This technique is being tested to program cells. Discover the latest research on genetic engineering to program cells here.

Neurotoxicity, Inflammation & Neuroprotection (Preprints)

The end result of the inflammatory process, neurotoxicity and/or neuroprotection, is a function of the fine balance between the two cellular systems, i.e., of the complex signaling relationships between anti-inflammatory neuroprotective factors (neurotrophins and other chemical mediators) and proinflammatory neurotoxic factors (tnf, free radicals, certain cytokines, etc). Here are the latest preprints pertaining to neurotoxicity, inflammation and neuroprotection.

PVN Neurons from iPSCs

Induced pluripotent stem cells (iPSCs) may be obtained by direct reprogramming of different somatic cells to a pluripotent state by forced expression of a handful of transcription factors. This feed focuses on the generation of neurons of the paraventricular nucleus of the hypothalamus from iPSCs.

BioRxiv Preprints

BioRxiv is the preprint server for biology, operated by Cold Spring Harbor Laboratory. Here are the latest biology preprint articles from bioRxiv.

Vertebrate Retinal Development

Retinal development in vertebrae is a complex molecular process that is regulated by several signal transduction pathways, including the Sonic hedgehog signaling pathway. Here is the latest research.

Neuromuscular Junction Diseases

Diseases of the neuromuscular junction cause skeletal muscle fatigue and include inherited and acquired disorders that affect presynaptic, intrasynaptic or postsynaptic components. Discover the latest research on neuromuscular junction diseases here.

Senescence in Diabetic Retinopathy

Diabetes has been found to induce premature senescence of endothelial retinal cells. An increase in senescence-associated cytokines has been found in patients with diabetic retinopathy. Understanding the mechanism and preventing this from occurring is of great importance. Here is the latest research on senescence and diabetic retinopathy.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Organ Regeneration

Regeneration in humans is the regrowth of tissues or organs in response to injury or damage. Discover the latest research on organ neuroregeneration here.

Glial Cell Differentiation

Glial cells play an essential role in maintaining brain homeostasis, forming myelin, and providing support and protection for neurons. Follow new research into glia cell differentiation with this feed.

© 2019 Meta ULC. All rights reserved

Cis-Regulatory Accessibility Directs Muller Glial Development and Regenerative Capacity

bioRxiv

Sep 3, 2019

Thomas Andrew RehKristen E Cox

DOI: 10.1101/752428

Abstract

Diseases of the retina can lead to losses in neurons and vision. Although the mammalian retina has no inherent regenerative capabilities, fish robustly regenerate from Muller glia (MG). Driving expression of Ascl1 in adult mouse MG stimulates neurogenesis; however, Ascl1-expressing MG p...read more

Mentioned in this Paper

DNA
Glioma
Laboratory mice
Myasthenia Gravis
Nerve Regeneration
4
3

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Get paper from

/papers/cis-regulatory-accessibility-directs-muller-glial/990752428