May 28, 2014

Cis-regulatory Elements and Human Evolution

BioRxiv : the Preprint Server for Biology
Adam Siepel, Leonardo Arbiza

Abstract

Modification of gene regulation has long been considered an important force in human evolution, particularly through changes to cis -regulatory elements (CREs) that function in transcriptional regulation. For decades, however, the study of cis -regulatory evolution was severely limited by the available data. New data sets describing the locations of CREs and genetic variation within and between species have now made it possible to study CRE evolution much more directly on a genome-wide scale. Here, we review recent research on the evolution of CREs in humans based on large-scale genomic data sets. We consider inferences based on primate divergence, human polymorphism, and combinations of divergence and polymorphism. We then consider “new frontiers” in this field stemming from recent research on transcriptional regulation.

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Mentioned in this Paper

Gene Polymorphism
Study
Transcriptional Regulation
Research
Genome
Cst8 protein, rat
Genomics
Primates
Location
Species

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