Cis-regulatory RNA elements that regulate specialized ribosome activity

RNA Biology
Shifeng Xue, Maria Barna

Abstract

Recent evidence has shown that the ribosome itself can play a highly regulatory role in the specialized translation of specific subpools of mRNAs, in particular at the level of ribosomal proteins (RP). However, the mechanism(s) by which this selection takes place has remained poorly understood. In our recent study, we discovered a combination of unique RNA elements in the 5'UTRs of mRNAs that allows for such control by the ribosome. These mRNAs contain a Translation Inhibitory Element (TIE) that inhibits general cap-dependent translation, and an Internal Ribosome Entry Site (IRES) that relies on a specific RP for activation. The unique combination of an inhibitor of general translation and an activator of specialized translation is key to ribosome-mediated control of gene expression. Here we discuss how these RNA regulatory elements provide a new level of control to protein expression and their implications for gene expression, organismal development and evolution.

References

Aug 27, 1990·Biochimica Et Biophysica Acta·P F Miller, A G Hinnebusch
Feb 1, 1980·The Journal of Experimental Zoology·H F Paterson
Oct 26, 2000·Trends in Genetics : TIG·M HolcikR G Korneluk
Mar 17, 2001·Nature Reviews. Genetics·D E Ferrier, P W Holland
Aug 21, 2001·Genes & Development·S PyronnetN Sonenberg
Mar 19, 2002·Genome Biology·Flavio MignoneGraziano Pesole
Oct 28, 2003·Nature Structural Biology·Peter J LukavskyJoseph D Puglisi
Apr 24, 2004·Science·Soraya YektaDavid P Bartel
May 21, 2005·Cellular and Molecular Life Sciences : CMLS·S PyronnetN Sonenberg
Sep 6, 2007·Nature Reviews. Molecular Cell Biology·Alwin Köhler, Ed Hurt
Apr 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sarah E CalvoVamsi K Mootha
May 23, 2009·Nature Reviews. Molecular Cell Biology·Paul Anderson, Nancy Kedersha
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Tara AlexanderRobb Krumlauf
Apr 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ryan B PaulsenDarrell R Davis
Jan 12, 2011·Cell Cycle·Anton A Komar, Maria Hatzoglou
Jan 25, 2011·Molecular Cell·Franck MartinGilbert Eriani
Mar 8, 2011·Nucleic Acids Research·Margarita MuhsChristian M T Spahn
Jul 29, 2011·Wiley Interdisciplinary Reviews. RNA·Nadeem Siddiqui, Katherine L B Borden
Mar 2, 2012·Genetics·Kristan K SteffenBrian K Kennedy
May 24, 2012·Nature Reviews. Molecular Cell Biology·Shifeng Xue, Maria Barna
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Amy Si-Ying LeeSean P J Whelan
May 14, 2014·Nature Reviews. Genetics·Stefanie A MortimerJennifer A Doudna
Sep 27, 2014·Biochimica Et Biophysica Acta·Mame Daro Faye, Martin Holcik
Oct 4, 2014·Molecular Cell·Takashi FukayaYukihide Tomari
Oct 4, 2014·Molecular Cell·Akira FukaoToshinobu Fujiwara

❮ Previous
Next ❯

Citations

Jun 29, 2016·RNA Biology·Thomas Philipp HoernesMatthias David Erlacher
Mar 21, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Cai ChenChengyi Song
Oct 3, 2018·ELife·Justin RendlemanChristine Vogel
Feb 14, 2019·Acta Neuropathologica·Shon A KorenJose F Abisambra
Feb 9, 2019·RNA·Max B Ferretti, Katrin Karbstein
Dec 4, 2016·Cellular and Molecular Life Sciences : CMLS·Rafaela LacerdaLuísa Romão
Jun 9, 2018·Cancers·Virginie MarcelJean-Jacques Diaz
Feb 8, 2020·Cell Stem Cell·Bernadette A ChuaRobert A J Signer

❮ Previous
Next ❯

Methods Mentioned

BETA
targeted knockout

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved