Cisapride decreases gastroesophageal reflux in preterm infants

Pediatrics
R L AriagnoR B Baldwin

Abstract

Gastrointestinal prokinetic agents, such as cisapride, are commonly used in pediatric practice to improve gastric emptying, to decrease emesis, to improve lower esophageal sphincter tone, and to improve irritability and feeding aversion associated with gastroesophageal reflux (GER). Although cisapride seems to be effective in infants from 2 months to 14 years old, data for younger and preterm infants are not available. Whether reflux is a significant cause of reflex apnea or feeding intolerance in the preterm infant is controversial. The objective of this 1-year prospective study, started in 1998, was to determine the efficacy of cisapride for treatment of reflux and reflux-associated apnea (RAAP) in preterm infants. Before this study, the diagnosis of reflux was often made clinically and the effect of therapy on reflux or the decision to increase the dose of cisapride was made empirically. The clinical bias was that persistent apnea, not responding to caffeine, was caused by GER. We reasoned that a systematic approach to the diagnosis and treatment of reflux would improve the care of preterm infants and reduce the risk of toxicity, especially if an increased dose of cisapride showed no improvement in reflux or apnea. Twenty-fo...Continue Reading

Citations

Apr 7, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Dawn E ElderAngela J Campbell
Feb 16, 2005·Biology of the Neonate·Eleanor J MolloyRichard J Martin
Aug 2, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Marije J SmitsMerit M Tabbers
Mar 16, 2002·Journal of Perinatology : Official Journal of the California Perinatal Association·Satbir ChhinaNidia R Vyhmeister
Sep 16, 2004·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Shawna M Henry
Jan 31, 2002·World Journal of Gastroenterology : WJG·M SunY K Han
Oct 15, 2008·Arquivos De Gastroenterologia·Maria Aparecida Mezzacappa, Ana Cecília Rosa
Jul 31, 2021·Nature Reviews. Disease Primers·Ronnie FassMichael F Vaezi

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