PMID: 9165590Apr 1, 1997Paper

Cisapride enhances detrusor contractility and improves micturition in a woman with lazy bladder

Scandinavian Journal of Urology and Nephrology
G P FranceschettiM Tonini

Abstract

A 32-year-old woman with lazy bladder was treated with cisapride (10 mg q.i.d.) for three weeks, obtaining a progressive improvement of the symptomatology and urodynamic parameters, and the return to pretreatment conditions after drug withdrawal. This case agrees with the evidence that cisapride potentiates the release of acetylcholine from postganglionic cholinergic nerves in the human isolated detrusor by activating 5-HT4 receptors, i.e. through the same mechanism responsible for its gastrointestinal prokinetic action. It is concluded that selective 5-HT4 agonists could be potentially useful to improve bladder emptying in micturition disorders associated with detrusor hypocontractility.

References

Jun 1, 1988·Paraplegia·G H de Groot, G F de Pagter
Jun 1, 1995·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·J TackJ Janssens

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Citations

May 10, 2002·Journal of Veterinary Pharmacology and Therapeutics·M Koutsoviti-PapadopoulouG Kounenis
Oct 22, 2005·Clinical Neuropharmacology·Giovanni PolimeniEdoardo Spina
Feb 18, 2009·Journal of Gastroenterology and Hepatology·Toru HiyamaKazuaki Chayama
Mar 21, 2013·Autonomic Neuroscience : Basic & Clinical·F Aura KullmannKarl B Thor
Jul 26, 2002·Pharmacoepidemiology and Drug Safety·K L L MovigA C G Egberts
Nov 17, 2004·Scandinavian Journal of Urology and Nephrology. Supplementum·Samih Al-HayekPaul Abrams
Apr 23, 2014·Current Opinion in Urology·Karl-Erik Andersson

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