PMID: 8591070Oct 1, 1995Paper

Cisapride for constipation in spinal cord injured patients: a preliminary report

The Journal of Spinal Cord Medicine
W E LongoF E Johnson

Abstract

Chronic constipation in patients with spinal cord injury (SCI) has significant impact on quality of life. To measure baseline clinical functioning, colonic transit time and anorectal manometry and the effect of cisapride on these clinical and physiological parameters, we studied 12 SCI patients. Patients initially received baseline clinical scoring, measurement of colonic transit time and anorectal manometry. Patients then received cisapride 20 mg orally three times each day. After one and three months of cisapride therapy, all measurements were repeated. The mean duration cisapride treatment was 5.2 months. Six of 12 (50 percent) reported that symptoms of constipation improved. No patient had worsening of symptoms. Prior to cisapride treatment, 23 percent of patients passed colonic transit markers by day five and 57 percent by day seven; baseline anal manometry revealed variable resting and squeeze pressures. After treatment, 33 percent of patients passed their colonic transit markers by day five and 71 percent by day seven. Six of 12 (50 percent) demonstrated a 10 percent or more increase in resting anal canal pressures. We conclude that about 50 percent of SCI patients have subjective improvement in constipation after cisapr...Continue Reading

References

Jun 1, 1988·Paraplegia·G H de Groot, G F de Pagter

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Citations

Mar 6, 2013·Topics in Spinal Cord Injury Rehabilitation·William A BaumanAnn M Spungen
Feb 19, 2019·Topics in Spinal Cord Injury Rehabilitation·Mohamed-Amine ChoukouSander L Hitzig
Mar 12, 1999·Annual Review of Medicine·B Coulie, M Camilleri
Mar 24, 2005·The American Journal of Gastroenterology·Davendra Ramkumar, Satish S C Rao
May 8, 2001·European Journal of Gastroenterology & Hepatology·P H WieselM A Kamm
Mar 1, 1997·Archives of Physical Medicine and Rehabilitation·C S FormalS A Stiens
Mar 1, 1997·Archives of Physical Medicine and Rehabilitation·S A StiensL L Goetz

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