PMID: 9437408Jan 23, 1998Paper

Cisapride increases peak plasma and saliva ethanol levels under fasting conditions

Journal of Internal Medicine
G DziekanW H Reinhart

Abstract

Alcohol absorption is influenced by gastric first-pass metabolism through an alcohol dehydrogenase and the gastric emptying time. Whilst an influence of antisecretory drugs and aspirin on gastric alcohol metabolism has been described, the role of prokinetic drugs has not been determined. A randomized, placebo-controlled double-blind cross-over study was performed. Out-patient facilities of a referral hospital. Eight male volunteers (age range 25-46 years). Treatment with two doses of either placebo or cisapride 150 micrograms/kg 7 h and 20 min before drinking 0.5 g/kg alcohol either in a fasting state or during a standardized meal (12 kcal/kg). Plasma and saliva ethanol concentrations were measured during 4 h. Cisapride increased peak plasma ethanol levels in fasting subjects from 15.6 (SD 1.4, 95%-KI 14.7;16.6) to 17.8 (SD 2.7, 95%-KI 15.9;19.7) mmol/L and saliva ethanol 30 min after alcohol ingestion from 11.4 (SD 2.2. 95%-KI 9.9;12.9) to 15.9 (SD 4.3, 95%-KI 12.9;18.8) mmol/L. A significant interaction between fasting state and drug intake was found for the 30 min saliva ethanol values (P < 0.05, ANOVA for repeated measurements). Cisapride may increase ethanol levels under fasting conditions. Patients treated with prokinetic...Continue Reading

References

Jun 1, 1992·The Journal of Clinical Investigation·T SmithM D Levitt
Jul 5, 1990·The New England Journal of Medicine
Aug 23, 1990·The New England Journal of Medicine·O M Brown

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Citations

Dec 14, 1999·British Journal of Clinical Pharmacology·S KechagiasA W Jones

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