Cisplatin and carboplatin-based chemotherapy in the first-line treatment of non-small cell lung cancer: Analysis from the European FRAME study

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Egbert SmitPhilipp A Schnabel

Abstract

To explore patient and disease factors, and reasons behind the physician's choice of platinum backbone for the first-line treatment of non-small cell lung cancer (NSCLC), as observed in a European prospective observational study of patients receiving platinum-based chemotherapy as first-line treatment for advanced or metastatic NSCLC (the FRAME study). Additionally, overall survival (OS) for patients who received cisplatin or carboplatin was evaluated. A post-hoc analysis of the prospective study population was conducted. Baseline characteristics of patients receiving cisplatin versus carboplatin were compared and summarized by propensity score. Survival for matched patients was summarized using the Kaplan-Meier approach. Of the 1564 patients who were included in the prospective study, 1520 received either cisplatin (54%) or carboplatin (46%) in combination with pemetrexed, gemcitabine, taxanes or vinorelbine. Patients treated with carboplatin were older than patients receiving cisplatin (mean age 67 versus 61 years; p<0.001), had poorer performance status (p<0.001), and more comorbidities (p<0.001). Cisplatin was most frequently combined with pemetrexed (47%), and carboplatin most frequently with taxanes (31%). Unadjusted medi...Continue Reading

References

Jun 7, 2007·Journal of the National Cancer Institute·Andrea ArdizzoniUNKNOWN CISCA (CISplatin versus CArboplatin) Meta-analysis Group
Oct 9, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Philipp A SchnabelDenis Moro-Sibilot
Mar 26, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Rafael Santana-DavilaJeff Whittle
Aug 15, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ReckUNKNOWN ESMO Guidelines Working Group
Mar 10, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Denis Moro-SibilotPhilipp A Schnabel

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Citations

Jan 14, 2020·The Cochrane Database of Systematic Reviews·Vitor F VasconcellosRachel Riera
Jun 17, 2019·Bulletin du cancer·Xavier MignardMarie Wislez
Sep 17, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ulla von VerschuerUNKNOWN TLK-Group (Tumour Registry Lung Cancer)

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