PMID: 8610633Apr 1, 1996Paper

Cisplatin and UFT modulated with leucovorin for the treatment of Advanced non-small-cell lung cancer

American Journal of Clinical Oncology
J FeliuI de la Gandara

Abstract

We performed a phase II study to assess the efficacy and toxicity of the cisplatin-UFT-leucovorin (LV) combination in patients with advanced non-small-cell lung cancer (NSCLC). Twenty-five patients with measurable disease who had not received prior chemotherapy were entered into the trial. The therapeutic regimen consisted of cisplatin 90 mg/m(2) and i.v. LV 500 mg/m(2) on day 1, followed by oral UFT 390 mg/m(2)/day (in two doses on days 1 through 14. Patients also received oral LV 15 mg/12 h on days 2 through 14. Seventeen patients required reduced doses of UFT (200 mg/m(2) due to toxicity. Courses were repeated every 28 days for a minimum of three per patient. Three of 25 patients (12%) achieved a partial response (95% CI: 2.6 to 32.2%), two with 390 mg/m(2)/day and one with 200 mg/m(2)/day of UFT. The main side effects were hematological and gastrointestinal. In the courses including 390 mg/m(2)/day of UFT, grade 3-4 toxicity was leucopenia in 18% of the courses, nausea/vomiting in 27%, and diarrhea and epigastralgia in 13% each. Grade 3-4 toxicities for 200 mg/m(2)/day of UFT were leucopenia 2%, nausea/vomiting 9% and diarrhea 7%. In conclusion, this regimen cannot be recommend for the treatment of advanced NSCLC due to its...Continue Reading

References

Nov 1, 1992·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E E VokesM R Green
Dec 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W HeimD Alt
Dec 1, 1990·British Journal of Cancer·S T MalikM L Slevin
Jan 1, 1981·Cancer·A B MillerA Winkler

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Citations

Sep 28, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Manuel González BarónAlvaro Pinto Marín
Jun 6, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·A M Jiménez-GordoM González-Barón
Oct 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·C J Langer

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