Cisplatin-based chemoradiotherapy with 5-fluorouracil or pemetrexed in patients with locally advanced, unresectable esophageal squamous cell carcinoma: A retrospective analysis

Molecular and Clinical Oncology
Zengyun LiTao Zhou

Abstract

Treatment with 5-fluorouracil (5-FU) and cisplatin (PF regimen) remains the most frequently used chemotherapy for esophageal squamous cell carcinoma (SCC). The aim of the present study was to assess the efficacy and safety of pemetrexed/cisplatin (PP regimen) as definitive treatment compared with PF. A total of 60 patients with locally advanced, unresectable SCC of the esophagus receiving concomitant chemoradiotherapy were recruited in this study; of those patients, 29 received four cycles (two concomitant and two post-radiotherapy) of the PF regimen (arm A, cisplatin 25 mg/m(2)/day i.v. on days 1-3 plus 5-FU 800 mg/m(2)/24 h by continuous infusion on days 1-5) and 31 received four cycles of the PP regimen (arm B, cisplatin 25 mg/m(2)/day i.v. on days 1-3 plus pemetrexed 500 mg/m(2) on day 1). All the patients in both arms received a total radiation dose of 59.6 Gy. The two arms were well-matched for age, gender, Karnofsky performance status, TNM stage, tumor location and length. The overall response rate was 89.7% in arm A vs. 93.5% in arm B (P>0.05). The median overall survival was 26.1 months [95% confidence interval (CI): 15.3-36.8 months] in arm A vs. 28.7 months (95% CI: 9.4-48.0 months) in arm B (P>0.05). Severe esophagi...Continue Reading

References

Jul 1, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·X H ShiT Liu
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D MinskyDavid P Kelsen
May 2, 2003·Expert Review of Anticancer Therapy·Alex A Adjei
Aug 7, 2003·Seminars in Radiation Oncology·Andy TrottiPhilip Rubin
Mar 23, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam C BergerMelvyn Goldberg
Apr 18, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P TherasseJ Verweij
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tanguy Y SeiwertEverett E Vokes
Apr 15, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Katsuhiko HiguchiKazushige Hayakawa
Sep 8, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Bao-sheng LiLi-ying Wang
Sep 28, 2010·Chinese Journal of Cancer·Zhi-Guo ZhouPing Zhang
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Ken KatoUNKNOWN Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group (JCOG)
Oct 27, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Aminah JatoiSteven R Alberts
Nov 16, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Bao-Sheng LiJ-M Yu
Feb 12, 2011·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y W ZhangX Zheng
Mar 10, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V M VillaflorE E W Cohen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

© 2022 Meta ULC. All rights reserved