Cisplatin combined with carboplatin: a new way of intensification of platinum dose in the treatment of advanced ovarian cancer. Belgian Study Group for Ovarian Carcinoma

Journal of the National Cancer Institute
M J PiccartC Gompel


We performed a phase I-II trial of escalating doses of cisplatin (CDDP: 50-100 mg/m2 per course) plus carboplatin (CBDCA: 300-400 mg/m2 per course) as a potential way in which to maximize platinum doses without causing excessive toxic effects in patients with advanced ovarian cancer. Thirty-three patients with nonoptimally debulked disease of FIGO (International Federation of Gynecology and Obstetrics) stages IIc-IV [median age: 60 yr; median WHO (World Health Organization) performance status: 2; no prior chemotherapy] received a median of six courses of therapy. CBDCA was infused on day 1 and CDDP on day 2 with an aggressive 48-hour hydration regimen. Myelosuppression was dose-limiting: at the highest dose levels, WHO grade 4 neutropenia and thrombocytopenia led to dose reduction and/or treatment delay in 45% of the patients. Nonhematologic toxic effects included acute nausea and vomiting (97% of the patients), mild alopecia (45%), ototoxic effects (39%), neurotoxic effects (21%), and renal toxic effects (serum creatinine greater than 1.5 mg/dL: 12.5%). The pathologic complete response rate was 22%. We conclude that CBDCA and CDDP can be given safely in combination at reasonably high doses (CBDCA at 300 mg/m2 per course and CD...Continue Reading


Sep 1, 1992·Seminars in Surgical Oncology·H I Scher, L Norton
Jan 1, 1992·Cancer Chemotherapy and Pharmacology·R P PerezT C Hamilton
Jan 1, 1993·Cancer Chemotherapy and Pharmacology·H SaitoT Miyachi
Jun 27, 2002·Journal of the Association for Research in Otolaryngology : JARO·Lian DingRichard J Salvi
Nov 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Benedetti-PaniciR Serafini
Jan 1, 1995·Critical Reviews in Oncology/hematology·M A Morgan, S C Rubin
May 9, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ch DittrichUNKNOWN Austrian Ovarian Cancer Study Group
Aug 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P SouliéE Cvitkovic
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M. SuzukiI. Sato
Feb 1, 1997·American Journal of Clinical Oncology·R NakanishiK Yasumoto
Jul 28, 2001·American Journal of Clinical Oncology·J Lokich
May 1, 1994·The Australian & New Zealand Journal of Obstetrics & Gynaecology·F HicksD Dodwell
Jan 1, 1992·Cancer Investigation·R J Schilder, R F Ozols
Jan 1, 1995·Clinical Oncology : a Journal of the Royal College of Radiologists·K J Harrington, H E Lambert
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F Doz, R Pinkerton
Jun 2, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G AravantinosUNKNOWN Hellenic Cooperative Oncology Group

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