Cisplatin decreases the abundance of aquaporin water channels in rat kidney.

Journal of the American Society of Nephrology : JASN
Soo-Wan KimKi-Chul Choi

Abstract

The present study examined whether the cisplatin induced urinary concentration defect can be related to an altered regulation of aquaporin (AQP) water channels in the kidney. Cisplatin (8 mg/kg) was injected intraperitoneally into male Sprague-Dawley rats. The control group was without cisplatin treatment. Four d later, the expression of AQP1, AQP2, and AQP3 proteins was determined in the kidney. To specify further the primary point of derangement in the pathway that activates the arginine vasopressin-mediated AQP channels, different components of adenylyl cyclase complex were examined separately. The cisplatin treatment caused a polyuric renal failure in association with decreases of free water reabsorption. The expression of AQP1 and AQP2 was decreased in the cortex, the outer medulla, and the inner medulla, whereas that of AQP3 was decreased in the outer medulla and the inner medulla. The expression of AQP2 proteins in the apical membrane-enriched fraction decreased in parallel with that in the subapical vesicle-enriched fraction, indicating a preserved targeting. Immunohistochemistry of the outer medulla also revealed that cisplatin decreased immunoreactivity for AQP1, AQP2, and AQP3. The arginine vasopressin-evoked generat...Continue Reading

References

Dec 1, 1992·The American Journal of Physiology·I SabolićD Brown
Sep 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·A L SteinerC Parker
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P C Sternweis, A G Gilman
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A Knepper
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·S NielsenM A Knepper
Apr 1, 1995·The Journal of Clinical Investigation·D MarplesS Nielsen
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S NielsenH W Harris
Jan 1, 1993·Nephron·N L WongR A Sutton
Oct 1, 1995·Kidney International·S Nielsen, P Agre
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·J SchnermannA S Verkman

❮ Previous
Next ❯

Citations

Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Soo Wan KimJongun Lee
Dec 12, 2001·Kidney International·C A EcelbargerB K Kishore
Aug 7, 2013·Experimental Biology and Medicine·Zhiyao ChenHeguang Huang
Jun 5, 2001·Japanese Journal of Pharmacology·J LeeK C Choi
Sep 13, 2003·Pharmacology & Toxicology·Eun-Jin SohnHo-Sub Lee
Mar 3, 2004·Biological & Pharmaceutical Bulletin·Dae Gill KangHo Sub Lee
Aug 10, 2006·Néphrologie & thérapeutique·Corinne Isnard-BagnisGilbert Deray
May 27, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sik LeeSung Kwang Park
Aug 9, 2020·Environmental Science and Pollution Research International·Azza M A Abo-ElmaatyMohamed M Abdel-Daim
Apr 21, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eun Hui BaeSoo Wan Kim
Jun 12, 2009·International Journal of Radiation Oncology, Biology, Physics·Jeremias HeyThomas Kuhnt
Jan 30, 2010·The American Journal of Pathology·Giuliano CiarimboliEberhard Schlatter
Jun 1, 2007·Electrolyte & Blood Pressure : E & BP·Eun Hui BaeSoo Wan Kim
Jan 29, 2011·Acta Physiologica·B TusgaardJ Frøkiaer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Society of Nephrology : JASN
Soo Wan KimJongun Lee
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Chung Ho YeumJongun Lee
© 2021 Meta ULC. All rights reserved