Cisplatin dose rate as a risk factor for nephrotoxicity in children

British Journal of Cancer
R SkinnerA W Craft

Abstract

The purpose of the study was to evaluate the incidence, risk factors and changes in severity with time of cisplatin nephrotoxicity in children. A total of 35 children underwent measurement of glomerular filtration rate (GFR) and tubular function after completion of cisplatin chemotherapy. No child received ifosfamide. A clinically relevant 'nephrotoxicity score' was derived from GFR and serum magnesium. Follow-up studies were performed in 16 children at 1 year and in 15 at 2 years after cisplatin. Considerable interpatient variability in nephrotoxicity was observed. Treatment was modified in three patients because of nephrotoxicity. GFR was low in 18 out of 31 patients. Proximal nephron toxicity caused hypomagnesaemia in ten patients and hypocalcaemia in five patients. Elevated urinary N-acetylglucosaminidase excretion was seen in 22 out of 30 children, indicating subclinical tubular toxicity. Nephrotoxicity was less severe in children who received cisplatin courses at a dose rate of 40 mg m(-2) day(-1) than in those who received higher dose rates (P < 0.005), but there was no correlation with total dose received. Follow-up studies revealed partial recovery of GFR (P < 0.05). Glomerular and proximal nephron toxicity are common ...Continue Reading

Citations

Jun 5, 2008·Pediatric Blood & Cancer·Marika H GrönroosToivo T Salmi
Oct 24, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wendy LandierSmita Bhatia
Nov 22, 2015·Cancer Chemotherapy and Pharmacology·Antonio RuggieroRiccardo Riccardi
Apr 14, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Sheron LatchaCarlos D Flombaum
May 25, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Alaa N A FahmiHatem A Salem
Jun 22, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Katarzyna MusiolHalina Wos
May 26, 2018·Pediatric Blood & Cancer·Ryu YanagisawaTomohiko Nakamura
Feb 13, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Wiem Ben AyedYosra Yahyaoui
Sep 30, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Antonio RuggieroGiorgio Attinà
Aug 27, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jacob Atsmon, Eran Dolev
Aug 31, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Morgan FinkelHoward Trachtman
Dec 3, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Mustafa ArgaOguz Soylemezoglu
Dec 18, 2018·Journal of Pediatric Hematology/oncology·Trine G BonnesenUNKNOWN ALiCCS Study Group
Jan 18, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Raed S IsmailMemy H Hassan
Jul 23, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Qi YangSong Zhang
Feb 8, 2006·Journal of Pediatric Hematology/oncology·Abha A GuptaSheila Weitzman
Feb 18, 2004·Pediatric Blood & Cancer·Thorsten LangerUNKNOWN German Late Effects Working Group in the German Society of Pediatric Oncology and Hematology
Feb 26, 2009·Current Urology Reports·Margarett ShnorhavorianMartin A Koyle
Aug 5, 2008·Pediatric Blood & Cancer·Deborah P JonesUNKNOWN Children's Oncology Group
Jul 4, 2015·Clinical Pharmacokinetics·Frederique RodieuxMarc Pfister
Apr 7, 2017·Journal of Nephrology·Sandhya Manohar, Nelson Leung
Apr 5, 2017·BMC Nephrology·Linda Awdishu, Ravindra L Mehta
Apr 24, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Roderick Skinner
Jan 23, 2018·Nature Reviews. Nephrology·John A Kellum, John R Prowle
Mar 7, 2003·Journal of Pediatric Hematology/oncology·Toshio KakiharaMakoto Uchiyama
Jan 30, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ludwig Patzer
Apr 25, 2020·International Journal of Inflammation·Eman Aly KhalifaAhmad Gad Allah
Sep 24, 2020·International Journal of Molecular Sciences·Ingrid Lilienthal, Nikolas Herold
Sep 26, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Renée L MulderLeontien C M Kremer
Jan 23, 2021·Expert Opinion on Drug Safety·Mariella Spalato, Antoine Italiano
Aug 8, 2020·Expert Opinion on Drug Metabolism & Toxicology·Debashree MukherjeaLeonard Rybak
Mar 4, 2021·Journal of the American Society of Nephrology : JASN·Daniel M GreenMelissa M Hudson
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xianxian GaoTie Hong
Jun 15, 2016·Molecular Pharmaceutics·Yu-Hsuan ChuRobert M Strongin
Apr 5, 2007·Cancer Cell International·S A Sharifah SakinahL P Azimahtol Hawariah

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.