Cisplatin Encapsulation Generates Morphologically Different Multicompartments in the Internal Nanostructures of Nonlamellar Liquid-Crystalline Self-Assemblies

Langmuir : the ACS Journal of Surfaces and Colloids
Intan D M AzmiAnan Yaghmur

Abstract

Cisplatin ( cis-diamminedichloroplatinum(II)) is among the most potent cytotoxic agents used in cancer chemotherapy. The encapsulation of cisplatin in lipid-based drug carriers has been challenging owing to its low solubility in both aqueous and lipid phases. Here, we investigated cisplatin encapsulation in nonlamellar liquid-crystalline (LC) nanodispersions formed from a ternary mixture of phytantriol (PHYT), vitamin E (Vit E), and an anionic phospholipid [either phosphatidylglycerol (DSPG) or phosphatidylserine (DPPS)]. We show an increase in cisplatin encapsulation efficiency (EE) in nanodispersions containing 1.5-4 wt % phospholipid. The EE was highest in DPPS-containing nanodispersions (53-98%) compared to DSPG-containing counterparts (25-40%) under similar experimental conditions. Through structural and morphological characterizations involving synchrotron small-angle X-ray scattering and cryogenic transmission electron microscopy, we further show that varying the phospholipid content of cisplatin-free nanodispersions triggers an internal phase transition from a neat hexagonal (H2) phase to a biphasic phase (internal H2 phase coexisting with the lamellar (Lα) phase). However, cisplatin encapsulation in both DPPS- and DSPG...Continue Reading

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Citations

Jun 6, 2019·Physical Chemistry Chemical Physics : PCCP·Anan YaghmurWinnie Edith Svendsen
Dec 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anan YaghmurSeyed Moein Moghimi
Jan 27, 2019·Therapeutic Delivery·Gizem BorAnan Yaghmur
Aug 1, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dan LiuAihua Zou
Dec 24, 2019·Frontiers in Bioengineering and Biotechnology·Anan YaghmurStefan Salentinig
Feb 11, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Carolina Del Valle BessoneDaniel Alberto Allemandi
May 18, 2021·Acta Pharmaceutica Sinica. B·Anan Yaghmur, Huiling Mu
Oct 31, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hossein Derakhshankhah, Samira Jafari

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