PMID: 9445186Jan 28, 1998Paper

Cisplatin, ifosfamide, and prolonged oral etoposide in the treatment of patients with extensive small cell lung carcinoma

Cancer
B GlissonW K Hong

Abstract

The combination of cisplatin, ifosfamide, and prolonged oral etoposide (PIE) was studied in patients with extensive small cell lung carcinoma (SCLC) in a Phase I trial followed by a Phase II trial to determine the maximum tolerated dose (MTD), characterize toxicity, and estimate response and median survival rates. Thirty-three patients were treated between October 1991 and December 1994. Doses for the initial cohort were cisplatin 20 mg/m2/day, ifosfamide 1500 mg/m2/day with mesna (all given intravenously on Days 1-3), and oral etoposide 50 mg/m2 on Days 4-17. This cycle was repeated every 4 weeks for up to 6 cycles. The MTD was reached for the first 9 patients. For these 9 patients and the next 24 patients, who were entered in the Phase II trial, response and survival were estimated. Dose-limiting toxicity was manifested as Grade 4 neutropenia in 3 of 3 patients (associated with fever in 2 of 3), and Grade 4 thrombocytopenia was encountered in 2 of 3 patients at the second dose level. Of 6 patients treated at the first dose level, 4 achieved targeted myelosuppression (absolute granulocyte count nadir <1000), but only 1 experienced Grade 4 neutropenia, defining this level as the MTD. Grade 4 neutropenia and/or thrombocytopenia ...Continue Reading

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Citations

Apr 23, 2002·The British Journal of Dermatology·E I CamposG Li
Oct 1, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·David J StewartB Nebiyou Bekele
Dec 17, 2003·The British Journal of Dermatology·Y-C KimB-K Ahn
Mar 24, 2015·Molecular and Clinical Oncology·Huizhen YangLijun Ma
Mar 29, 2001·Irish Journal of Medical Science·T M O'ConnorN Brennan
Apr 3, 1999·Current Opinion in Oncology·K NishioN Saijo
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B S GlissonW K Hong

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