Cisplatin increases the number of enterochromaffin cells containing substance P in rat intestine

Naunyn-Schmiedeberg's Archives of Pharmacology
Yusuke ObaraM Hirafuji

Abstract

We previously reported that cisplatin potentiated ileal 5-hydroxytryptamine (5-HT) metabolism and caused pathological changes with an inflammatory response in the delayed phase (72 h) after administration to rats. In the present study, we further investigated the time-dependent effect of cisplatin on ileal 5-HT metabolism and the effects of combining cisplatin and anti-inflammatory drugs on ileal tryptophan hydroxylase expression and pica (the consumption of non-nutritive materials such as kaolin). Cyclooxygenase-2 (COX-2) expression was significantly increased at 24 h after cisplatin (5 mg/kg, intraperitoneal) administration. Cisplatin significantly increased ileal 5-HT content at 48 h after administration and the number of L-tryptophan hydroxylase-expressing cells (i.e., enterochromaffin cells) in the ileal mucosa within 24 h after administration. It also caused a significant increase in the number of substance P-expressing cells. Immunohistochemical double staining revealed that most of the enterochromaffin cells contained substance P. Neither daily treatment with dexamethasone (1 mg/kg, subcutaneous) nor meloxicam (3 mg/kg, subcutaneous), a selective COX-2 inhibitor, affected the cisplatin-induced increase in the number of ...Continue Reading

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Citations

Nov 8, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Marta Martín-RuízRaquel Abalo
Oct 5, 2019·Biological & Pharmaceutical Bulletin·Maiko MachidaMasahiko Hirafuji
Aug 8, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rita J Wickham
Jun 3, 2021·International Journal of Molecular Sciences·Weixia ZhongNissar A Darmani

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