Cisplatin induces modifications in the development of cell surface patterns of ciliates

Cell Biology International
S MachweG R Sapra

Abstract

Cisplatin [cis-dichlorodiammineplatinum (II)] brings about significant quantitative modifications in the development of cell surface patterns in two unrelated ciliates: Stylonychia and Tetrahymena. Cells cultured in the presence of cisplatin exhibit the formation of supernumerary surface structures in the form of extra cilia/cirri (fused cilia) and other organized ciliary organelles. The metal-induced formation of extra primordia and their differentiation into supernumerary ciliary structures is governed by the normal rules of development. Additional structures are accommodated within the framework of a defined pattern, suggesting the existence of an overall global control of pattern formation. The modified pattern is rectified to its normal state during post-treatment fission cycles, suggesting the role of the cell membrane in correcting developmental errors.

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Citations

Jan 17, 2019·International Journal of Systematic and Evolutionary Microbiology·Jeeva Susan AbrahamRavi Toteja
Apr 23, 2004·Molecular Pharmacology·Xing-Jie LiangMichael M Gottesman

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