Cisplatin-loaded hollow gold nanoparticles for laser-triggered release

Cancer Nanotechnology
Chiyi XiongChun Li

Abstract

Hollow gold nanoparticles (HGNPs) exposed to near-infrared (NIR) light yield photothermal effects that can trigger a variety of biological effects for potential biomedical applications. However, the mechanism of laser-triggered drug release has not been studied before. A tripeptide Ac-Glu-Glu-Cys-NH2 (Ac-EEC) was directly linked to the surface of HGNPs. The EEC-HGNPs conjugate was then complexed with cisplatin Pt(II) to give Ac-EEC(Pt)-HGNPs. Folic acid was introduced to the gold surface of Ac-EEC-HGNPs through a thioctic acid-terminated polyethylene glycol linker (F-PEG-TA) followed by complexation with Pt(II) to give F-Ac-EEC(Pt)-HGNPs. Laser treatment was instituted with a 15-ns pulsed laser at a repetition rate of 10 Hz. The released Pt(II) was quantified by inductively coupled plasma mass spectroscopy, and the nature of the released Pt-containing species was characterized by liquid chromatography-mass spectroscopy. The cytotoxicity was studied using the MTT assay. Pt(II) was released from Ac-EEC(Pt)-HGNPs via two modes: (1) sustained release through an inverse ligand exchange reaction with chloride ions and (2) rapid release through cleavage of the Au-S bond between the tripeptide linker and Au surface upon NIR laser irrad...Continue Reading

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Citations

May 13, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Fengrong ZhangHuiyu Liu
May 9, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Muhammad Asim FarooqBo Wang
Dec 12, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Danushika C ManatungaK M Nalin de Silva
Jan 19, 2021·Journal of Pharmaceutical Sciences·Mehreen RehmanM Aslam Zia
Nov 3, 2021·Journal of Chemical Information and Modeling·Felipe J ValenciaJosé Rogan
Dec 10, 2021·Nanomedicine·Tânia Ferreira-GonçalvesCatarina P Reis

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Methods Mentioned

BETA
surface plasmon resonance
transmission electron microscopy
dynamic light scattering
X-ray
transfection

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