Cisplatin Radiosensitization of DNA Irradiated with 2-20 eV Electrons: Role of Transient Anions

The Journal of Physical Chemistry. C, Nanomaterials and Interfaces
Qianhong BaoLéon Sanche

Abstract

Platinum chemotherapeutic agents, such as cisplatin (cis-diamminedichloroplatinum(II)), can act as radiosensitizers when bound covalently to nuclear DNA in cancer cells. This radiosensitization is largely due to an increase in DNA damage induced by low-energy secondary electrons, produced in large quantities by high-energy radiation. We report the yields of single- and double-strand breaks (SSB and DSB) and interduplex cross-links (CL) induced by electrons of 1.6-19.6 eV (i.e., the yield functions) incident on 5 monolayer (ML) films of cisplatin-DNA complexes. These yield functions are compared with those previously recorded with 5 ML films of unmodified plasmid DNA. Binding of five cisplatin molecules to plasmid DNA (3197 base pairs) enhances SSB, DSB, and CL by factors varying, from 1.2 to 2.8, 1.4 to 3.5, and 1.2 to 2.7, respectively, depending on electron energy. All yield functions exhibit structures around 5 and 10 eV that can be attributed to enhancement of bond scission, via the initial formation of core-excited resonances associated with π → π* transitions of the bases. This increase in damage is interpreted as arising from a modification of the parameters of the corresponding transient anions already present in nonmod...Continue Reading

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Citations

Jan 13, 2015·Annual Review of Physical Chemistry·Elahe AlizadehLéon Sanche
Aug 12, 2017·International Journal of Radiation Biology·Yanfang DongYi Zheng
Nov 24, 2016·Physical Chemistry Chemical Physics : PCCP·Wenzhuang ChenLéon Sanche
Mar 10, 2018·Chemistry : a European Journal·Robin SchürmannIlko Bald
Aug 21, 2019·International Journal of Molecular Sciences·Anil KumarMichael D Sevilla
Aug 3, 2019·International Journal of Molecular Sciences·Yi Zheng, Léon Sanche
Aug 21, 2019·Journal of Oncology·Minghan Shi, Léon Sanche
Aug 8, 2021·International Journal of Molecular Sciences·Yingxia GaoLéon Sanche

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