PMID: 9179666Jan 1, 1997Paper

Cisplatin, vincristine, methotrexate, peplomycin, etoposide (COMPE) therapy for disseminated germ cell testicular tumors

International Journal of Urology : Official Journal of the Japanese Urological Association
K YoshimuraT Kawai

Abstract

The advent of cisplatin rendered disseminated testicular germ cell tumor an often curable malignant disease. Patients with a heavy metastatic burden, however, remain poor risks; furthermore, many patients experience nausea or other adverse events. This paper reports a trial of a cisplatin-based (COMPE) combination chemotherapy regimen based on synchronization theory. Twenty patients with disseminated germ cell testicular tumors were treated with COMPE; any residual tumor mass was surgically resected. Seventeen patients (85%) achieved complete remission by chemotherapy. The actuarial overall and cause-specific 3-year survival rates were 89% and 94%, respectively. In the subset of 16 "good-risk" patients, all remain alive after a median follow-up of 43 months. Complications were quite tolerable, with nephrotoxicity in particular being extremely mild. COMPE is an effective chemotherapy regimen in patients with disseminated germ cell testicular tumors. Complications arising from this therapy are mild.

References

Mar 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R BirchF A Greco
Jun 1, 1986·British Journal of Urology·E S NewlandsL Holden
Oct 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G J BoslM Bains
Jun 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R F OzolsR C Young
Mar 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C J LogothetisA C von Eschenbach
Apr 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P J LoehrerS D Williams
Apr 1, 1994·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·T UedaJ Yonese
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y RemvikosP Pouillart
Feb 1, 1994·Experimental Cell Research·N ShinomiyaM Rokutanda

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Citations

Oct 6, 2011·Journal of Experimental & Clinical Cancer Research : CR·Laetitia FinziRobert Malafosse
Oct 9, 2013·The Cochrane Database of Systematic Reviews·Sebastiaan L KnijnenburgMonique W M Jaspers
Mar 12, 2019·The Cochrane Database of Systematic Reviews·Esmee Cm KooijmansMargreet A Veening

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