PMID: 9524084Apr 2, 1998Paper

Cisplatin/vincristine chemotherapy for hypothalamic/visual pathway astrocytomas in young children

Journal of Neuro-oncology
Tsutomu KatoH Abe

Abstract

Hypothalamic/visual pathway astrocytomas in children are usually quiescent, but certain cases contain aggressive neoplasms that cause progressive neurological and visual deterioration. Radiotherapy is not recommended in young children because of its adverse effects later in life. This report describes the efficacy of a chemotherapeutic regimen. Four young children with hypothalamic/visual pathway astrocytoma, with a mean of 18 months of age at diagnosis, were treated with chemotherapy. Three patients had diencephalic syndrome at the disease's onset. Three patients with pilocytic astrocytoma were histologically verified, and another infant was clinically diagnosed. A combination chemotherapy using cisplatin and vincristine was administered in a total of 8 cycles in 3 children and 4 in one child. One patient who demonstrated renal insufficiency after 4 cycles of this regimen was treated with additional 4 cycles using carboplatin instead of cisplatin. The acute and subacute hematologic and otologic toxicities were mild, and a transient renal insufficiency in a child during chemotherapy improved. After chemotherapy, tumor regression was documented in 3 patients, and the disease was observed to be stable in one patient with an evide...Continue Reading

Citations

Feb 20, 2009·Japanese Journal of Clinical Oncology·Yutaka SawamuraJunko Tsubaki
Feb 3, 2011·Journal of Korean Neurosurgical Society·Sung-Hyun KimShin Jung
Apr 25, 2000·Journal of Pediatric Gastroenterology and Nutrition·D ErtemE Pehlivanoglu
Oct 29, 2003·British Journal of Neurosurgery·J Astrup
May 3, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Michimasa NozakiYutaka Sawamura
Mar 3, 2015·Korean journal of pediatrics·Ahlee KimJeong Kee Seo
Oct 5, 2006·Eye·L M Kaufman, O Doroftei
Feb 6, 2003·Cancer·Maryam FouladiRichard L Heideman
Jul 10, 2008·Neuro-oncology·Yutaka SawamuraTakamitsu Fujimaki
Mar 5, 2008·Cancer Research·Balazs HegedusDavid H Gutmann
Oct 15, 2020·Neurotoxicology·Gui-Zhou LiJing Xu

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